TADA2A
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Official Full Name
transcriptional adaptor 2A -
Overview
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. -
Synonyms
ADA2;ADA2A;KL04P;hADA2;TADA2L;FLJ12705;transcriptional adapter 2-alpha;ADA2-like protein;OTTHUMP00000164062;OTTHUMP00000164063;transcriptional adaptor 2 alpha;TADA2A;transcriptional adaptor 2A
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Rat
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TADA2A-16381M | Recombinant Mouse TADA2A Protein | Mammalian Cells | Mouse | His |
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| TADA2A-2035C | Recombinant Chicken TADA2A | Mammalian Cells | Chicken | His |
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| TADA2A-4603Z | Recombinant Zebrafish TADA2A | Mammalian Cells | Zebrafish | His |
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| TADA2A-5910R | Recombinant Rat TADA2A Protein | Mammalian Cells | Rat | His |
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| TADA2A-1280HCL | Recombinant Human TADA2A 293 Cell Lysate | HEK293 | Human | Non |
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| TADA2A-1281HCL | Recombinant Human TADA2A 293 Cell Lysate | HEK293 | Human | Non |
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| TADA2A-126H | Recombinant Human TADA2A Protein, His-tagged | E.coli | Human | His |
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| TADA2A-5569R | Recombinant Rat TADA2A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| TADA2A-5569R-B | Recombinant Rat TADA2A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| TADA2A-8961M | Recombinant Mouse TADA2A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TADA2A-8961M-B | Recombinant Mouse TADA2A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TADA2A involved in several pathways and played different roles in them. We selected most pathways TADA2A participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with TADA2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | SMARCB1A,ATXN7L3,SAP30L,KDM5BB,KDM5BA,SMARCB1B,C3orf75,KDM5B,USP22,ACTL6B |
| HATs acetylate histones | PHF15,PHF17,VPS72,SAP130,PAX3A,BRPF1,RBB4L,ING5,C3orf75,ING5A |
| Chromatin organization | PBRM1,BRD8,KANSL2,KAT6B,KDM2A,JADE1,MCRS1,ACTL6A,GATAD2A,PAX3A |
Protein Function
TADA2A has several biochemical functions, for example, DNA binding,chromatin binding,contributes_to histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TADA2A itself. We selected most functions TADA2A had, and list some proteins which have the same functions with TADA2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GCHFR,SPEG,BRD4,SEPT1,MPHOSPH6,INHBA,KIF20B,BMPR1A,IFI35,FNBP1 |
| DNA binding | HOXB4A,MNX2B,RORAA,POLR3C,FOXQ1A,SUPT3H,ZNF763,ZNF358,PC,LHFP |
| zinc ion binding | RNF121,CPE,RBM14B,TRIM35-31,PDLIM5B,SHANK3,ZDHHC18A,CPA5,DHH,ARIH2 |
| transcription factor activity, sequence-specific DNA binding | POU2F2,MYNN,SLAMF7,NKX2-5,ZNF354B,NFYAL,REST,RUNX2,SLC30A9,BHLHE22 |
| transcription coactivator activity | PMF1,RUNX1,CRSP7,SMARCD1,SAP130,NR2F1,PER2,SUB1,PML,SIX3 |
| chromatin binding | DLX3,JMJD5,BAZ1B,ESR1,MKRN1,FOSL2,HOXD10,ARX,SREBF1,MITF |
| contributes_to histone acetyltransferase activity | EPC1,TAF10,KAT2A,SUPT7L,TAF6L,TEX30,TADA3,KAT5,ING3,TAF12 |
| transcription cofactor activity | ZNF710,ZFP667,PIR,WDR75,MAP3K7,ZNF710A,MED14,ZNF212,NMI,ANKRA2 |
Interacting Protein
TADA2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TADA2A here. Most of them are supplied by our site. Hope this information will be useful for your research of TADA2A.
PRPF31;EIF4E2;MTX2;FARS2;MFAP1;MAGOH;SF3A3
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References
- Martin, M; Geudens, I; et al. PP2A regulatory subunit B alpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. EMBO JOURNAL 32:2491-2503(2013).
- Zhang, J; Wang, S; et al. Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-alpha-induced NF-kappa B activation by interacting with p65/RelA and p50/NF-kappa B1. MEDICAL MICROBIOLOGY AND IMMUNOLOGY 202:313-325(2013).
