TAB1
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Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 1 -
Overview
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
3"-Tab1;MGC57664;MAP3K7IP1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;OTTHUMP00000199134;OTTHUMP00000199135;TAK1-binding protein 1;transforming growth factor beta-activated kinase-binding protein 1;mitogen-activated protein kinase kinase kinase 7-interacting protein 1;TAB1;TGF-beta activated kinase 1/MAP3K7 binding protein 1
Recombinant Proteins
- Chicken
- Human
- Mouse
- Rhesus macaque
- Mammalian Cells
- E.coli
- HEK293
- His
- His&T7
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TAB1 involved in several pathways and played different roles in them. We selected most pathways TAB1 participated on our site, such as Activated TLR4 signalling,C-type lectin receptors (CLRs),CLEC7A (Dectin-1) signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FCERI mediated NF-kB activation | RASGRP2 |
| Activated TLR4 signalling | TNIP2,S100A12,IRAK3,PELI2,TIRAP,CREB1B,DUSP4,PELI3,JUN,TANK |
| Death Receptor Signalling | FAM105B,SHARPIN,RNF31,CLIP3,OTULINB,TAX1BP1,USP2,USP4,RBCK1,OTULIN |
| Fc epsilon receptor (FCERI) signaling | GRAP2A,LCP2A,GRAP2B,RASGRP2,ITK,LAT2 |
| CLEC7A (Dectin-1) signaling | CASP8L1,MALT1,IL1B2,UBE2V1,AHCYL1 |
| C-type lectin receptors (CLRs) | CLEC4D,UBE2V1,AHCYL1,CLEC6A,CLEC4A,ITPR2,MALT1,CREBBP,IL1B2,CASP8L1 |
| Epstein-Barr virus infection | RBPJ,POLR1C,HLA-C,ICAM1,SYK,EIF2AK2,EP300,EIF2AK1,HLA-DRB1,YWHAB |
| Cytokine Signaling in Immune system | CISH,EIF4EB,GBP6,SPTA1,HLA-DQB2,TRIM5,FGF8B,TNFRSF13C,ARIH1,NUPL2 |
Protein Function
TAB1 has several biochemical functions, for example, enzyme activator activity,kinase activator activity,mitogen-activated protein kinase p38 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAB1 itself. We selected most functions TAB1 had, and list some proteins which have the same functions with TAB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine phosphatase activity | PPP3CB,MTMR6,PPM1J,CDC14AA,CTDNEP1B,PPEF1,PPM1DB,PPM1LB,PPM1BA,PPA2 |
| protein binding | SMNDC1,GRIN2A,CASKIN1,CHCHD1,ETV5,CREM,CXXC5,IPO13,RAD51L3,CEP85 |
| protein complex binding | INS2,OTOF,PPP1R9B,PFKP,PRMT5,FYB,MYO7A,AKAP5,PPARA,CRHR1 |
| kinase activator activity | MOBKL1A,ITSN1 |
| mitogen-activated protein kinase p38 binding | RPS6KA4,NFATC1,SPAG9,PRMT1 |
| enzyme activator activity | LTC4S,PITRM1,HSPB2,GM749,ARL1,SLX4,DCP1A,PSAPL1,PRKCE,DBNL |
Interacting Protein
TAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAB1.
TAB2;MAPK14;MAP3K7;HSPA1L;MAP3K7;HSP90AA1;ARRB2
Resources
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References
- Wellhauser, L; Belsham, DD; et al. Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons. JOURNAL OF NEUROINFLAMMATION 11:-(2014).
- Ozawa, T; Piao, XH; et al. A Novel Rabbit Immunospot Array Assay on a Chip Allows for the Rapid Generation of Rabbit Monoclonal Antibodies with High Affinity. PLOS ONE 7:-(2012).
