SYT5
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Official Full Name
synaptotagmin V -
Overview
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related;to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may;act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium;receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 (PubMed 7597049)). -
Synonyms
SYT5;synaptotagmin V;synaptotagmin-5;synaptotagmin 5;sytV
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
SYT5 involved in several pathways and played different roles in them. We selected most pathways SYT5 participated on our site, such as Integration of energy metabolism,Metabolism,Regulation of insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | ESRRA,ARSH,PFKLB,SLC35D2,NDUFA11,VAPB,NHLRC1,GLYAT,SLC46A1,BHMT2 |
| Integration of energy metabolism | KCNS3,KCNB1,MARCKSB,MARCKSA,KCNC2,AKAP5,KCNJ11,GNB5A,GNG13A,KCNS3A |
| Regulation of insulin secretion | KCNS3,MARCKSB,MARCKSA,ARL2,KCNB1,KCNS3A,KCNC2,ARL2BP |
Protein Function
SYT5 has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipid binding,clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT5 itself. We selected most functions SYT5 had, and list some proteins which have the same functions with SYT5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| syntaxin binding | SYT13,NAPAA,STXBP1,TXLNG,VAMP2,SYT11,CXorf15,TMED10,SYT16,SYT1A |
| protein heterodimerization activity | BMP2B,GCLC,IKZF2,MID1,SDCBP2,PANX2,DR1,TLX1,HOMER1,SUPT3H |
| calcium-dependent phospholipid binding | ANXA4,C2CD4A,SYT2,DOC2B,ANXA3B,SYT7B,SYT17,SYT5A,SYT9,SYT11 |
| clathrin binding | SYT1,SYT1A,HIP1R,SYTL2,TOM1,SYT7,SYT10,SNAP91,SYT6,CLINT1 |
| calcium ion binding | AIF1,CIB3,LDLR,ANXA7,ITIH1,NUCB1,GPD2,CDH24,MFGE8B,TNNC1A |
Interacting Protein
SYT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT5.
POLR2E;RAB1A
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References
- Strotmeier, J; Mahrhold, S; et al. Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A. FEBS LETTERS 588:1087-1093(2014).
- Stafford, JH; Hao, GY; et al. Highly Specific PET Imaging of Prostate Tumors in Mice with an Iodine-124-Labeled Antibody Fragment That Targets Phosphatidylserine. PLOS ONE 8:-(2013).
