SUV420H2
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Official Full Name
suppressor of variegation 4-20 homolog 2 (Drosophila) -
Overview
SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically;trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 (PubMed;15145825)). -
Synonyms
SUV420H2;suppressor of variegation 4-20 homolog 2 (Drosophila);histone-lysine N-methyltransferase SUV420H2;KMT5C;MGC2705;FLJ98627;Histone lysine N methyltransferase SUV420H2;Lysine N methyltransferase 5C;Su(var)4 20 homolog 2;Suppressor of variegation 4 20 homolog 2;Suv4 20h2;suv4-20h2;OTTHUMP00000197477;su(var)4-20 homolog 2;lysine N-methyltransferase 5C
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- His&GST
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SUV420H2-1174H | Recombinant Human SUV420H2 protein(Gly2-Leu280), His&GST-tagged | E.coli | Human | His&GST | Gly2-Leu280 |
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| SUV420H2-16264M | Recombinant Mouse SUV420H2 Protein | Mammalian Cell | Mouse | His |
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| SUV420H2-212H | Recombinant Human SUV420H2 Protein, GST-tagged | Insect Cell | Human | GST | 1-462 |
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| SUV420H2-27744TH | Recombinant Human SUV420H2 | E.coli | Human | Non | 2-280 a.a. |
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| SUV420H2-474H | Recombinant Human SUV420H2, GST-tagged | E.coli | Human | GST | 2-280 a.a. |
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| SUV420H2-5657Z | Recombinant Zebrafish SUV420H2 | Mammalian Cell | Zebrafish | His |
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| SUV420H2-5845R | Recombinant Rat SUV420H2 Protein | Mammalian Cell | Rat | His |
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| SUV420H2-1331HCL | Recombinant Human SUV420H2 293 Cell Lysate | HEK293 | Human | Non |
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| SUV420H2-5504R | Recombinant Rat SUV420H2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SUV420H2-5504R-B | Recombinant Rat SUV420H2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SUV420H2-8890M | Recombinant Mouse SUV420H2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SUV420H2-8890M-B | Recombinant Mouse SUV420H2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SUV420H2 involved in several pathways and played different roles in them. We selected most pathways SUV420H2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUV420H2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | ALDH7A1,SETD7,WBP7,TMLHE,HADH,SETDB2,SETDB1,SETD2,ALDH2.1,SETD1BA |
Protein Function
SUV420H2 has several biochemical functions, for example, histone methyltransferase activity (H4-K20 specific),protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUV420H2 itself. We selected most functions SUV420H2 had, and list some proteins which have the same functions with SUV420H2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CD200R2,RRP8,TSR2,MRPL49,RBP4,EIF4A1,NRADD,USP9X,PTS,DFFA |
| histone methyltransferase activity (H4-K20 specific) | SUV420H1,WHSC1,NSD1 |
Interacting Protein
SUV420H2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUV420H2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUV420H2.
CBX3;Dlg4;CBX5;CBX1;HTR7
Resources
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References
- Fullgrabe, J; Heldring, N; et al. Cracking the survival code Autophagy-related histone modifications. AUTOPHAGY 10:556-561(2014).
- Kapoor-Vazirani, P; Vertino, PM; et al. A Dual Role for the Histone Methyltransferase PR-SET7/SETD8 and Histone H4 Lysine 20 Monomethylation in the Local Regulation of RNA Polymerase II Pausing. JOURNAL OF BIOLOGICAL CHEMISTRY 289:7425-7437(2014).
