SUDS3
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Official Full Name
suppressor of defective silencing 3 homolog (S. cerevisiae) -
Overview
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex;(Fleischer et al., 2003 (PubMed 12724404)). -
Synonyms
SUDS3;suppressor of defective silencing 3 homolog (S. cerevisiae);suppressor of defective silencing 3 homolog (SDS3, S. cerevisiae);sin3 histone deacetylase corepressor complex component SDS3;FLJ00052;SAP45;SDS3;sin3A associated protein;45kDa;2400003N08Rik;2410008L21Rik;45 kDa Sin3 associated polypeptide;AU067672;MGC104711;mSds3;RGD1305986;SDS3, yeast, homolog of;Sin3A associated protein 45kDa;Suppressor of defective silencing 3;Suppressor of defective silencing 3 homolog (S cerevisiae);Suppressor of defective silencing 3 homolog (SDS3 S cerevisiae);Suppressor of defective silencing 3 protein homolog;sin3A-associated protein, 45kDa;45 kDa Sin3-associated polypeptide
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Human
- Mammalian Cells
- HEK293
- His
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SUDS3-16212M | Recombinant Mouse SUDS3 Protein | Mammalian Cells | Mouse | His |
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| SUDS3-3118C | Recombinant Chicken SUDS3 | Mammalian Cells | Chicken | His |
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| SUDS3-936Z | Recombinant Zebrafish SUDS3 | Mammalian Cells | Zebrafish | His |
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| SUDS3-1363HCL | Recombinant Human SUDS3 293 Cell Lysate | HEK293 | Human | Non |
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| Suds3-6217M | Recombinant Mouse Suds3 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| SUDS3-6384H | Recombinant Human SUDS3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| SUDS3-8855M | Recombinant Mouse SUDS3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| SUDS3-8855M-B | Recombinant Mouse SUDS3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SUDS3 involved in several pathways and played different roles in them. We selected most pathways SUDS3 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUDS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Negative epigenetic regulation of rRNA expression | TAF1B,SIN3B,DNMT1,EFCAB11,DNMT3B,SAP30L,TAF1C,SAP30BP,RRP8,TAF1A |
| Chromatin organization | TADA1,SAP130,MSL2,PBRM1,KDM5BB,MORF4L1,KAT6A,RBBP4,SMARCA2,MTA3 |
| Chromatin modifying enzymes | RBBP7,SAP30L,ACTL6B,PHF20B,WDR77,RBBP5,KDM5BB,EED,SMARCB1B,SMYD3 |
| NoRC negatively regulates rRNA expression | BAZ2A,SIN3B,TAF1D,SAP130,DNMT1,TAF1A,TAF1C,SAP30L,EFCAB11,TAF1B |
| HDACs deacetylate histones | ARID4A,SAP30,SAP30L,KDM1A,SAP18,BRMS1,MTA3,MTA1,CHD4A,MTA2 |
| Epigenetic regulation of gene expression | UHRF1,TAF1A,JARID2,SAP30BP,TET2,RRP8,PHF19,CD3EAP,BAZ2A,TET1 |
| Gene Expression | EIF4B,GATAD2AB,COX6A1,NR1H3,ZNF19,ZNF41,ZNF155,ZNF223,ZKSCAN5,SNRNP48 |
Protein Function
SUDS3 has several biochemical functions, for example, enzyme binding,contributes_to histone deacetylase activity,histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUDS3 itself. We selected most functions SUDS3 had, and list some proteins which have the same functions with SUDS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DVL1,IPO11,KIAA0141,AUNIP,FH,SKAP2,SORBS2,DCLRE1B,GNB1B,PSMC3 |
| histone deacetylase binding | D7ERTD443E,HES1,SRF,HDAC9,NUDT21,DHX36,PKN2,MYOCD,PHB,KAT2A |
| contributes_to histone deacetylase activity | SIN3AA,SIN3A,BRMS1LA,BRMS1,BRMS1L,SALL1,SIN3B |
| enzyme binding | PIAS1,SIRT3,HOXA9,ZFHX3,BCHE,AKT1,NOXO1,HIST1H2AM,PTPLAD1,RAD9 |
Interacting Protein
SUDS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUDS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUDS3.
HDAC1;BRMS1;HCFC1;CSNK2A1;LRRK2;SRPK1;SAP30;Tet1;Sin3a;Fam60a;HDAC2
Resources
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References
- Zhang, K; Dai, XP; et al. Depletion of Suds3 reveals an essential role in early lineage specification. DEVELOPMENTAL BIOLOGY 373:359-372(2013).
- Silveira, AC; Hurst, DR; et al. Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells. CANCER LETTERS 276:32-37(2009).
