STK36
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Official Full Name
serine/threonine kinase 36 -
Overview
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. -
Synonyms
STK36;serine/threonine kinase 36;serine/threonine kinase 36 (fused homolog, Drosophila);serine/threonine-protein kinase 36;FU;fused homolog (Drosophila);KIAA1278;Fused homolog;Serine/threonine kinase 36, fused homolog;OTTHUMP00000164096;OTTHUMP00000164097;OTTHUMP00000206456
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| STK36-264H |
Active Recombinant Human STK36, GST-tagged
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Sf9 Cells | Human | GST | 1-457 a.a. |
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| STK36-16147M | Recombinant Mouse STK36 Protein | Mammalian Cells | Mouse | His |
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| STK36-4781Z | Recombinant Zebrafish STK36 | Mammalian Cells | Zebrafish | His |
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| STK36-1714HCL | Recombinant Human STK36 cell lysate | Human | Non |
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| STK36-8811M | Recombinant Mouse STK36 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| STK36-8811M-B | Recombinant Mouse STK36 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
STK36 involved in several pathways and played different roles in them. We selected most pathways STK36 participated on our site, such as Hedgehog signaling pathway,Pathways in cancer,Basal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK36 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal cell carcinoma | FZD2,APC2,BMP4,WNT9B,PTCH1,FZD8,TRP53,PTCH2,WNT4,FZD10 |
| Hedgehog signaling pathway | SAP18,WNT3,WNT11,WNT5A,WNT11B,GLI2B,SUFU,SKI,IHHB,WNT8B |
| Pathways in cancer | ITGA2B,HRAS,FGF3,MDM2,WNT1,CCDC6,PRKACA,GNG5,GNA12,FH1 |
Protein Function
STK36 has several biochemical functions, for example, ATP binding,magnesium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK36 itself. We selected most functions STK36 had, and list some proteins which have the same functions with STK36. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | DIP2C,HMGA1,DIP2A,ADD1,HDAC5,DIP2BA,ENPP2,FOXC1,PPARGC1A,DOT1L |
| protein binding | CSPP1,OBSCN,CAV1,GADD45G,FOXP4,RICTOR,HTR1A,EMILIN1,ZMYM5,HIST2H3C |
| magnesium ion binding | MARK2,TSSK3,HACL1,PKM2,HMGCL,ENO4,PIF1,GTPBP5,PPM1BB,CIB3 |
| protein serine/threonine kinase activity | DCLK1A,MAP3K4,STK30,PRKCI,NEK5,ULK4,MAP2K1,GRK7B,ACVR2A,DAPK2 |
| ATP binding | STK10,HSP90AA1.1,GRK4,SLC22A5,ACTR2B,YME1L1B,RIOK3,ERCC2,DHX32A,PIF1 |
Interacting Protein
STK36 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK36 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK36.
GLI1;GLI3;SUFU;ARMC6;Gli2;FRMPD4;MAST2;CLNK;CDK5RAP2
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References
- Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).
