STEAP2
-
Official Full Name
STEAP family member 2, metalloreductase -
Overview
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
STEAP2;STEAP family member 2, metalloreductase;PCANAP1, prostate cancer associated protein 1 , six transmembrane epithelial antigen of the prostate 2;metalloreductase STEAP2;IPCA 1;STAMP1;STMP;prostate cancer associated protein 1;prostate cancer
Recombinant Proteins
- Human
- Mus musculus
- E.coli
- HEK293
- Wheat Germ
- E.coli expression system
- In vitro E. coli expression system
- In Vitro Cell Free System
- His
- Non
- GST
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| STEAP2-3001H | Recombinant Human STEAP2, His-tagged | E.coli | Human | His | 155-265aa | |
| STEAP2-29478H |
Active Recombinant Human STEAP2 Full Length Transmembrane protein(Nanodisc)
|
HEK293 | Human | Non | Full L. |
|
| STEAP2-15H | Recombinant Human STEAP2 protein, GST-tagged | Wheat Germ | Human | GST | 1-490 a.a. |
|
| STEAP2-16H | Recombinant Human STEAP2 protein, GST-tagged | Wheat Germ | Human | GST | 2-100 a.a. |
|
| RFL23588HF | Recombinant Full Length Human Metalloreductase Steap2(Steap2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-490aa) |
|
| RFL27667MF | Recombinant Full Length Mouse Metalloreductase Steap2(Steap2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-489) |
|
| STEAP2-2454H | Recombinant Human STEAP2 Full Length Transmembrane protein, His-SUMO-tagged | In vitro E. coli expression system | Human | His&SUMO | Full L. 1-490aa |
|
| STEAP2-649HF | Recombinant Full Length Human STEAP2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 490 amino acids |
|
Involved Pathway
STEAP2 involved in several pathways and played different roles in them. We selected most pathways STEAP2 participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with STEAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mineral absorption | SLC11A2,TF,S100G,ATP1B2,HMOX2,MT1E,HEPH,ATP1A2,TRPV6,ATP1A3 |
Protein Function
STEAP2 has several biochemical functions, for example, cupric reductase activity,ferric-chelate reductase (NADPH) activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STEAP2 itself. We selected most functions STEAP2 had, and list some proteins which have the same functions with STEAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | SEC23IP,PHC2A,DPEP3,NOB1,ZNF354A,IDO1,BTR18,MT1,DDX59,ZNHIT2 |
| ferric-chelate reductase (NADPH) activity | STEAP4,STEAP3 |
| cupric reductase activity | STEAP4,STEAP3 |
| transporter activity | TMEM184BA,RLBP1,SLCO4C1,CHP,ATP6V0E1,CHP1,ABCA3,ABCA9,FLVCR1,PTGDS |
Interacting Protein
STEAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STEAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STEAP2.
Resources
Related Services
Related Products
References
- McCarthy, RC; Kosman, DJ; et al. Mechanistic analysis of iron accumulation by endothelial cells of the BBB. BIOMETALS 25:665-675(2012).
- Grunewald, TGP; Bach, H; et al. The STEAP protein family: Versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions. BIOLOGY OF THE CELL 104:641-657(2012).
- Vaghjiani, RJ; Talma, S; et al. Six-Transmembrane Epithelial Antigen of the Prostate (STEAP1 and STEAP2)-Differentially Expressed by Murine and Human Mesenchymal Stem Cells. TISSUE ENGINEERING PART A 15:2073-2083(2009).
