STAP1
-
Official Full Name
signal transducing adaptor family member 1 -
Overview
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. -
Synonyms
STAP1;signal transducing adaptor family member 1;signal-transducing adaptor protein 1;BCR downstream signaling 1;BRDG1;STAP 1;docking protein BRDG1;stem cell adaptor protein 1;BCR downstream-signaling protein 1;signal-transducing adaptor protein-
Recombinant Proteins
- Mouse
- Rat
- Human
- Rhesus macaque
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- N-His&C-Myc
Involved Pathway
STAP1 involved in several pathways and played different roles in them. We selected most pathways STAP1 participated on our site, such as B Cell Receptor Signaling Pathway,Kit Receptor Signaling Pathway,Signaling events mediated by Stem cell factor receptor (c-Kit), which may be useful for your reference. Also, other proteins which involved in the same pathway with STAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | CMTM3,DUSP6,CR2,MAPK4,NFKBIB,CD72,PIK3AP1,CTNNB2,PTPN18,RAP2A |
| Signaling events mediated by Stem cell factor receptor (c-Kit) | PTPRO,EVLA,MAP4K1,SH2B3 |
| Kit Receptor Signaling Pathway | SOCS4,GRB7,GRAP,PTPRUB,GRB10,DOK1,DOK1B,PTPRU,SPRED2B,GRAPA |
Protein Function
STAP1 has several biochemical functions, for example, SH3/SH2 adaptor activity,macrophage colony-stimulating factor receptor binding,phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAP1 itself. We selected most functions STAP1 had, and list some proteins which have the same functions with STAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane receptor protein tyrosine kinase adaptor activity | SHC1,GAB2,PIK3R1,SH2B2,FRS2,TRAT1,DOK2,IRS1,BLNK |
| protein kinase binding | GCET2,PTPRJ,CCNL1A,SLC12A4,KIF14,NGFRAP1,CEP68,PPP1R12B,PRKAB1,SPAG16 |
| macrophage colony-stimulating factor receptor binding | IL34,CSF1 |
| protein binding | MAPK4,C15orf57,GEMIN6,RPRD1B,ANK2,MAPK3,SHMT2,FBXO18,COBRA1,ANXA10 |
| phospholipid binding | DGKA,SHC1,GLTPD1,APOA2,PSD4,GOT2,SYT14,TEC,NUP35,F10 |
| SH3/SH2 adaptor activity | SLA,BLNK,LAT,SH3BGR,SLA2,GRB14,CHN2,KHDRBS1,CD28,CNTNAP1 |
| phosphotyrosine binding | SHC1,ACP2,SAMSN1,CBLC,GRB2,MAPK1,ZAP70,CBL,PTPN3,MAPK3 |
Interacting Protein
STAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAP1.
SH3KBP1;q5jpt6_human;FAM134C;MET;AR;KIT
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