ST6GALNAC4
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Official Full Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -
Overview
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ST6GALNAC4;ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4;sialyltransferase 7D ((alpha N acetylneuraminyl 2,3 beta galactosyl 1,3) N acetyl galactosaminide alpha 2,6 sialyltransferase) , SIA
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ST6GALNAC4-4344Z | Recombinant Zebrafish ST6GALNAC4 | Mammalian Cell | Zebrafish | His |
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| ST6GALNAC4-6080C | Recombinant Chicken ST6GALNAC4 | Mammalian Cell | Chicken | His |
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| ST6GALNAC4-981C | Recombinant Cynomolgus ST6GALNAC4 Protein, His-tagged | Mammalian Cell | Cynomolgus | His |
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| ST6GALNAC4-1436HCL | Recombinant Human ST6GALNAC4 293 Cell Lysate | HEK293 | Human | Non |
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| ST6GALNAC4-724C | Recombinant Cynomolgus Monkey ST6GALNAC4 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| ST6GALNAC4-724C-B | Recombinant Cynomolgus Monkey ST6GALNAC4 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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Involved Pathway
ST6GALNAC4 involved in several pathways and played different roles in them. We selected most pathways ST6GALNAC4 participated on our site, such as Glycosphingolipid biosynthesis - ganglio series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST6GALNAC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | MOGS,ACY1,RDH12,HOGA1,MGAT5,MOCS1,FBP1A,MAT2AL,ARG1,AKR1A1B |
| Glycosphingolipid biosynthesis - ganglio series | ST6GALNAC5,ST6GALNAC3,ST3GAL2,ST8SIA1,ST3GAL1,B3GALT4,GLB1,SLC33A1,B4GALNT1,ST6GALNAC6 |
Protein Function
ST6GALNAC4 has several biochemical functions, for example, (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity,alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity,sialyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST6GALNAC4 itself. We selected most functions ST6GALNAC4 had, and list some proteins which have the same functions with ST6GALNAC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | ST6GALNAC5B,ST6GALNAC1,ST6GALNAC5,ST6GALNAC3,ST6GALNAC6,ST6GALNAC1.2 |
| sialyltransferase activity | ST6GAL2B,ST8SIA5,ST6GAL1,ST3GAL2L,ST3GAL5L,ST6GALNAC1.2,ST6GALNAC3,ST6GALNAC5B,ST6GALNAC6,ST3GAL5 |
Interacting Protein
ST6GALNAC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST6GALNAC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST6GALNAC4.
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