ST5
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Official Full Name
suppression of tumorigenicity 5 -
Overview
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. -
Synonyms
ST5;suppression of tumorigenicity 5;suppression of tumorigenicity 5 protein;DENN/MADD domain containing 2B;DENND2B;HTS1;p126;DENN domain containing protein 2B;HeLa tumor suppression 1;DENN domain-containing protein 2B;ST 5;ST5_HUMAN
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ST5-476Z | Recombinant Zebrafish ST5 | Mammalian Cell | Zebrafish | His |
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| ST5-1439HCL | Recombinant Human ST5 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
ST5 involved in several pathways and played different roles in them. We selected most pathways ST5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ST5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ST5 has several biochemical functions, for example, Rab guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST5 itself. We selected most functions ST5 had, and list some proteins which have the same functions with ST5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rab guanyl-nucleotide exchange factor activity | SBF1,DENND6B,DENND4B,RABGEF1,DENND2A,DENND3,RIN3,DENND4C,DENND1A,DENND2D |
Interacting Protein
ST5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST5.
ABL1;SFN;GRB2;SMAD2;recC;Flot1;MYH9;Actb;PPP1CB;Myh10;LLGL2;Myh9;MYO18A;MYO19;Calml3;ANLN;Myo1c;Coro1c
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References
- Korkmaz, GA; Al, FD; et al. Investigation of the Presence of Blastocystis spp. in Stool Samples with Microscopic, Culture and Molecular Methods. MIKROBIYOLOJI BULTENI 49:85-97(2015).
- SATO, S; TAKAMATSU, N; et al. CONSTRUCTION OF MUTANTS OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS DEFECTIVE IN SEROTYPE-B-SPECIFIC POLYSACCHARIDE ANTIGEN BY INSERTION OF TRANSPOSON TN916. JOURNAL OF GENERAL MICROBIOLOGY 138:1203-1209(1992).
