SSH3
-
Official Full Name
slingshot homolog 3 -
Overview
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of;actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The;SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002;(PubMed 11832213)). -
Synonyms
SSH3;slingshot homolog 3 (Drosophila);protein phosphatase Slingshot homolog 3;FLJ10928;FLJ20515;SSH-3L;hSSH-3L;slingshot 3;SSH-like protein 3;SSH3L;FLJ42240
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SSH3 involved in several pathways and played different roles in them. We selected most pathways SSH3 participated on our site, such as Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with SSH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | MAPK1,RAC2,PDGFB,GNA12,WASL,ACTN2B,PIK3CA,KRAS,CDC42L,PIK3R1 |
Protein Function
SSH3 has several biochemical functions, for example, DNA binding,actin binding,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSH3 itself. We selected most functions SSH3 had, and list some proteins which have the same functions with SSH3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | MESP1,PAX6B,RXRAB,TRIM16,Ar,TDP2B,PROX1,TFEC,PPARA,ZFY2 |
| protein tyrosine/serine/threonine phosphatase activity | MTMR2,CDC14B,SSH2B,PTP4A3,DUSP13,CDC14AA,DUSP1,DUSP12,PTPMT1,CTDSPL2B |
| protein tyrosine phosphatase activity | DUSP2,PTPRO,MTMR7B,PTPRA,MTMR1,UBASH3B,PTPRF,PTPRZ1,DUSP22A,EVLA |
| actin binding | HDAC6,CCR5,NCALD,HOMER2,EVL,NF2,MPRIP,VMHCL,NRAP,TPMA |
Interacting Protein
SSH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSH3.
SORT1;TMEM248
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