SSH1
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Official Full Name
slingshot homolog 1 (Drosophila) -
Overview
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
SSH1;slingshot homolog 1 (Drosophila);protein phosphatase Slingshot homolog 1;KIAA1298;mSSH 1L;slingshot 1L;slingshot homolog 1;SSH 1;AW551225;Coro1c;coronin, actin binding protein 1C;Gm1394;Gm1395;hSSH-1L;OTTMUSP00000031415;Slingshot 1;slingshot like 1;Slingshot1;SSH 1L;SSH-1L;SSH-like protein 1;SSH1_HUMAN;SSH1L
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SSH1-2967H | Recombinant Human SSH1, His-tagged | E.coli | Human | His | 1-347aa | |
| SSH1-16029M | Recombinant Mouse SSH1 Protein | Mammalian Cells | Mouse | His |
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| SSH1-1460HCL | Recombinant Human SSH1 293 Cell Lysate | HEK293 | Human | Non |
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| SSH1-8744M | Recombinant Mouse SSH1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| SSH1-8744M-B | Recombinant Mouse SSH1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SSH1 involved in several pathways and played different roles in them. We selected most pathways SSH1 participated on our site, such as Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with SSH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | ACTN3A,MSNA,WASB,INS,PIK3R2,TMSB,ACTN2,RRAS,RHOA,MAPK6 |
Protein Function
SSH1 has several biochemical functions, for example, DNA binding,actin binding,phosphoprotein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSH1 itself. We selected most functions SSH1 had, and list some proteins which have the same functions with SSH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PPP4C,PIGK,TBL1XR1,PROL1,SIRT3,AGT,CAMTA2,CCDC9,TNP1,KIAA1274 |
| protein tyrosine/serine/threonine phosphatase activity | CDC14AB,DUSP16,PTPDC1,CDC14C,DUSP23A,PTP4A2B,DUSP5,DUSP10,DUSP23,DUSP8A |
| phosphoprotein phosphatase activity | CTDNEP1,PPP4CB,PTPREB,TENC1,PPM1H,PPP1CBL,PTPN2A,CTDNEP1B,PPM1DB,PHLPP1 |
| actin binding | TPM4,FHOD3,SYNPO2L,NCALD,TWF1A,SHROOM1,SPATA31,MSRB1A,DIAPH1,AVIL |
| DNA binding | SMARCB1,RAD51L3,ZNF19,IRX4B,HLFB,HMGA1B,HER13,ZNF317,NFE2L1A,HIST1H2BF |
| protein tyrosine phosphatase activity | TPTE,PTPDC1,MTMR14,PTPRQ,DUSP5,MTMR7,SSH2B,PTPRK,EVLA,PTPMT1 |
Interacting Protein
SSH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSH1.
LIMK1;YWHAQ;CORO1B;YWHAB;Coro1b;Arpc2;CFL1
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References
- Niwa, R; Nagata-Ohashi, K; et al. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. CELL 108:233-246(2002).
