SREBF1
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Official Full Name
sterol regulatory element binding transcription factor 1 -
Overview
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SREBF1;sterol regulatory element binding transcription factor 1;sterol regulatory element-binding protein 1;bHLHd1;SREBP 1c;SREBP1;SREBP-1;class D basic helix-loop-helix protein 1;SREBP-1c
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Cricetulus griseus
- Rat
- Mus musculus
- Sus scrofa (Pig)
- E.coli
- Mammalian Cell
- E.coli expression system
- in vitro E. coli
- HEK293
- His
- His&Fc&Avi
Involved Pathway
SREBF1 involved in several pathways and played different roles in them. We selected most pathways SREBF1 participated on our site, such as AMPK signaling pathway,Insulin signaling pathway,Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SREBF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | SLC27A1A,IRS2,PPARA,ACACB,PPP1CAA,AKT3A,PRKAG3B,FOXO1,PYGB,SLC2A1 |
| AMPK signaling pathway | AKT3,PFKFB2,RPS6KB1,PPP2R5D,IGF1,PRKAB1,IRS2,PFKFB4,RHEB,PPP2R1B |
| Non-alcoholic fatty liver disease (NAFLD) | RAC1,PPARA,UQCRB,IL1A,NDUFB1,SDHD,COX7B2,NDUFB10,NDUFAB1,NFKB1 |
| Insulin signaling pathway | PHKG1A,PTPRF,MAPK1,PRKAR2A,SHC2,HKDC1,PPP1CAA,INS,FBP2,PIK3R2 |
Protein Function
SREBF1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SREBF1 itself. We selected most functions SREBF1 had, and list some proteins which have the same functions with SREBF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | HER3,POLR2J2,FBXW11,MXD1,GPR139,PDCD6,POLR2J3,NPAS4,TWIST1A,HELT |
| sequence-specific DNA binding | DLX2A,GZF1,FOXK2,HOXB5A,OTX1B,MEOX2B,DMRT2B,GLI1,BHLHE22,MAFGB |
| protein kinase binding | CCNE2,CAV1,CCNT2B,PRKACA,ADIPOR1,HDAC7,CD36,IL31RA,MAP3K12,KCNA5 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NFIA,FOSL1A,EN1,NR1D1,MEOX2,TFE3,HOXA5,SIX5,NFE2L3,SP1 |
| transcription regulatory region DNA binding | EGR2,TBX16,DHX36,IKZF3,TRP63,TOMM20A,HIVEP3,MEF2C,ATF3,CCNT1 |
| transcription factor activity, sequence-specific DNA binding | CTNNB1,NKX2-5,EGR2B,HOXB8,ZNF397,IRF2,SMAD6,TEAD3,ENO1,CNBP |
| DNA binding | ZFP687,TBR1B,ZNF436,FOXG1D,ZNF572,PBX1B,PAX1,ALX4B,HOXA13B,TAF15 |
| chromatin binding | RNF168,LOXL2,PLAC8,TP53,RAD51,CITED2,FANCM,HMGN5,NCOA2,AIRE |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | TXK,MITF,CEBPB,ZNF750,EHF,POU1F1,CAMTA1,MESP1,CEBPA,ZFP750 |
Interacting Protein
SREBF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SREBF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SREBF1.
Sumo1;Hnf4a;Sirt1
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