SRD5A2
-
Official Full Name
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) -
Overview
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). -
Synonyms
SRD5A2;steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2);3-oxo-5-alpha-steroid 4-dehydrogenase 2;5 alpha SR2;3 oxo 5 alpha steroid 4 dehydrogenase 2;5 alpha-SR2;5ART2;e II 5 alpha reductase;EC;MGC138457;Micropenis, included;S5A2_HUMAN;S5AR 2;SR type 2;Steroid 5 alpha reductase 2;Steroid 5-alpha-reductase 2;Type II 5-alpha reductase;3-oxo-5 alpha-steroid 4-dehydrogenase 2
Recombinant Proteins
- Mouse
- Human
- Rat
- Cynomolgus
- Sus scrofa (Pig)
- Mus musculus
- Macaca fascicularis
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- Non
- His&GST
- N-His-KSI
- His&Fc&Avi
- GST
Involved Pathway
SRD5A2 involved in several pathways and played different roles in them. We selected most pathways SRD5A2 participated on our site, such as Steroid hormone biosynthesis,Prostate cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRD5A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Steroid hormone biosynthesis | CYP7A1A,CYP2C55,STS,PPP1R2,HSD17B3,CYP2C54,CYP3A7-CYP3AP1,CYP7B1,UGT1A1,UGT1A4 |
| Prostate Cancer | CREB3L3,PDPK1,INS,RAF1,GRB2,INSRR,MAP2K2,Ar,ERBB2,CREB3L1 |
Protein Function
SRD5A2 has several biochemical functions, for example, 3-oxo-5-alpha-steroid 4-dehydrogenase activity,amide binding,cholestenone 5-alpha-reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRD5A2 itself. We selected most functions SRD5A2 had, and list some proteins which have the same functions with SRD5A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholestenone 5-alpha-reductase activity | SRD5A3,SRD5A1 |
| amide binding | PHB2 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity | SRD5A2A,SRD5A3,PPP1R2,SRD5A2B,SRD5A1 |
Interacting Protein
SRD5A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRD5A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRD5A2.
Resources
Related Services
Related Products
References
- Ge, RB; Wang, ZW; et al. DNA Methyl Transferase 1 Reduces Expression of SRD5A2 in the Aging Adult Prostate. AMERICAN JOURNAL OF PATHOLOGY 185:870-882(2015).
- Kon, M; Suzuki, E; et al. Molecular basis of non-syndromic hypospadias: systematic mutation screening and genome-wide copy-number analysis of 62 patients. HUMAN REPRODUCTION 30:499-506(2015).
