SPTLC1
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Official Full Name
serine palmitoyltransferase, long chain base subunit 1 -
Overview
Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. -
Synonyms
SPTLC1;serine palmitoyltransferase, long chain base subunit 1;hereditary sensory neuropathy, type 1 , HSN1;serine palmitoyltransferase 1;hLCB1;HSAN1;LCB1;SPTI;HSAN;HSN1;LBC1;LCB 1;Long chain base biosynthesis protein 1;MGC14645;Serine C palmitoyltransferase;Serine palmitoyl CoA transferase 1;Serine palmitoyltransferase long chain base subunit 1;Serine palmitoyltransferase subunit 1;Serine-palmitoyl-CoA transferase 1;SPT 1;SPT1;SPTC1_HUMAN;SPTLC 1;serine C-palmitoyltransferase
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Pongo Abelii
- Cricetulus griseus
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- HEK293T
- Mammalian cells
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
SPTLC1 involved in several pathways and played different roles in them. We selected most pathways SPTLC1 participated on our site, such as Metabolic pathways,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTLC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid signaling pathway | PLCB3,CERS4,GAB2,HRAS,FCER1A,KRAS,AKT1,RAF1,GNAI1,RELA |
| Metabolic pathways | GAD2,CBS,NME1-NME2,THTPA,LASS4,G6PCA.2,COX17,IDH2,ALAS2,NMRK2 |
| ceramide de novo biosynthesis | SPTSSA |
| Sphingolipid de novo biosynthesis | COL4A3BP,ACER1,VAPB,PPM1L,PPM1LB,CERS4A,OSBP,GDF1,PPM1LA,CERS3B |
| Metabolism of lipids and lipoproteins | CYP27B1,ARSD,ACOT12,CTGF,FABP9,MED18,APOA5,AWAT1,ARSJ,DHCR24 |
| Sphingolipid metabolism | FA2H,CERS5,VAPB,GALCA,ARSH,SGMS2,ARSI,SUMF2,OSBP,CERS4 |
| Metabolism | PEMT,MED19,ACY3.1,APOC2,PAOX,SLC25A15,CKMB,SLC19A2,CYP2A13,APOEA |
Protein Function
SPTLC1 has several biochemical functions, for example, protein binding,pyridoxal phosphate binding,serine C-palmitoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTLC1 itself. We selected most functions SPTLC1 had, and list some proteins which have the same functions with SPTLC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine C-palmitoyltransferase activity | SPTLC3,SPTLC2 |
| pyridoxal phosphate binding | GPT2,ALAS1,CTH,GOT2A,GAD1,MARC2,Alb,KYNU,HDC,AGXT2L1 |
| protein binding | POMGNT1,UBR4,HMGB4,EID3,SPI1,SORT1,C10orf137,CRY1,SDCBP,PPARGC1A |
Interacting Protein
SPTLC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTLC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTLC1.
RGS20;ATG4C;C20orf24;MAGED1;tsr;Bub1;Zw10;MYC;1C;CFTR;Bmpr1a;JAK3;Ncstn;Rab5b;DYNLL1;Sptlc2;LRRK2;Atp7a;ARMC6
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References
- Hornemann, T; Wei, Y; et al. Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?. BIOCHEMICAL JOURNAL 405:157-164(2007).
