SPTBN1

  • Official Full Name

    spectrin, beta, non-erythrocytic 1

  • Overview

    Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    SPTBN1;spectrin, beta, non-erythrocytic 1;spectrin beta chain, brain 1;beta-fodrin;beta-G spectrin;beta-spectrin 2;beta-II spectrin;beta-spectrin II;fodrin beta chain;embryonic liver beta-fodrin;spectrin, non-erythroid beta chain 1;ELF;SPTB2

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Cynomolgus
  • E.coli
  • Mammalian Cells
  • C-His
  • HEK293
  • His
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SPTBN1-30885TH Recombinant Human SPTBN1, His-tagged E.coli Human His 280-692 a.a.
SPTBN1-4298C Recombinant Chicken SPTBN1 Mammalian Cells Chicken His
SPTBN1-4456R Recombinant Rhesus monkey SPTBN1 Protein, His-tagged Mammalian Cells Rhesus macaque His
SPTBN1-1639C Recombinant Cynomolgus SPTBN1 protein, His-tagged C-His Cynomolgus Phe17-Gln318
SPTBN1-200HCL Recombinant Human SPTBN1 cell lysate, Myc/DDK-tagged HEK293 Human Myc&DDK
SPTBN1-4272R Recombinant Rhesus Macaque SPTBN1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
SPTBN1-4272R-B Recombinant Rhesus Macaque SPTBN1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    SPTBN1 involved in several pathways and played different roles in them. We selected most pathways SPTBN1 participated on our site, such as ARMS-mediated activation,Axon guidance,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTBN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system PEA15,CISH,HERC5,TRIM17,EIF4E,GBP4,DUSP7,TRIM48,NOD1,TRIM10
    ARMS-mediated activation FGF18B,DAB2IPB,SPNA2,SPRED3,RASGRP4,RASGRP1,FGFR1B,JAK2,IL17RD,RASGEF1A
    DAP12 signaling NRG3,GRAP2B,DAB2IPB,RASGEF1A,FRS3,DUSP2,SPRED3,RASGRP1,PTPRA,AGO2
    Cell-Cell communication CDH5,CDH10,CDH8,CLDN23,CADM2B,ANG,CDH2,CDH24,CLDN3,CDH13
    Axon guidance IL17RD,NFATC2,KLB,SLIT1,ARPC1B,EPHB3,GSK3B,Ntng2,ARHGEF12,MAPK1
    DAP12 interactions FGF8B,GRAP2B,WDR83,FRS2,RASGEF1A,SPRED3,NRG4,SPRED1,NRG3,FGF10B
    Developmental Biology PEBP1,LGI1B,EPHB4A,AP2A1,ARPC1A,BOC,RASGRP1,JAK1,CACNG2,NADL1.1
    Downstream signal transduction SPRED1,TRAT1,CNKSR1,FGF8B,SPTB,PEA15,FRS3,FGF10B,SPRED3,AGO3

    Protein Function

    SPTBN1 has several biochemical functions, for example, GTPase binding,actin binding,ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTBN1 itself. We selected most functions SPTBN1 had, and list some proteins which have the same functions with SPTBN1. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding MYH9,CAMK1GB,CAMSAP1L1,CNN1A,MYH1E,ADD1,MYO1F,IQGAP3,CAMK4,GEM
    phospholipid binding PICALMB,STAP1,GOT2,APOC3,PON1,SEC14L2,NUP35,PRKCI,ESYT1,OSBPL1A
    ankyrin binding KCNJ11,RHBG,SCN5A,SLC8A1,RHAG,KCNQ2,OBSCN,NRCAM,CDH1,ATP1A1
    protein binding SOCS6,CTNNA1,TNKS2,RNF146,ELMO2,ROBO2,PABPC1,ATP6V0C,NSMAF,AHSA2
    GTPase binding IARS,BNIP3,GNB1,PTPRN,STOML2,ENO1,GM5506,LCP1,YBX1,AIMP1
    structural constituent of cytoskeleton DSP,SORBS3,SPTBN2,EPB41L4B,ACTG1,TUBAL3,BFSP2,ACTL7B,CYLC2,SPTAN1
    actin binding FMNL2,SNTG1,ARPC1A,DMTN,FER,WAS,SPNA1,FXYD5,ADD2,AVIL
    poly(A) RNA binding PPIA,PPRC1,CHTOP,RPS27L,ZNF346,U2AF2,CFAP20,CCT6A,NUPL2,ALDOA

    Interacting Protein

    SPTBN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTBN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTBN1.

    SPTA1;GRB2;CDC5L;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;spectrin_a1_a2_prot;SPTAN1

    Resources

    References

    • Lin, L; Yao, ZX; et al. Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC cAMP-response element-binding proteins ATF3 and CREB2. CARCINOGENESIS 35:2393-2403(2014).
    • Demiralp, DO; Haznedaroglu, IC; et al. Functional proteomic analysis of Ankaferd (R) Blood Stopper. TURKISH JOURNAL OF HEMATOLOGY 27:70-77(2010).

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