SPINK5
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Official Full Name
serine peptidase inhibitor, Kazal type 5 -
Overview
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SPINK5;serine peptidase inhibitor, Kazal type 5;serine protease inhibitor, Kazal type 5;serine protease inhibitor Kazal-type 5;DKFZp686K19184;FLJ21544;FLJ97536;FLJ97596;FLJ99794;LEKTI;LETKI;lymphoepithelial Kazal type related inhibitor;NETS;N
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPINK5-686H | Recombinant Human SPINK5 Protein, His-tagged | E.coli | Human | His | Gly699~Ser976 | |
| Spink5-687M | Recombinant Mouse Spink5 Protein, His-tagged | E.coli | Mouse | His | Cys734~Ala995 | |
| Spink5-688M | Recombinant Mouse Spink5 Protein, His/GST-tagged | E.coli | Mouse | His&GST | Cys734~Ala995 | |
| SPINK5-2328H | Recombinant Human SPINK5 protein(722-847aa), His-GST&Myc-tagged | E. coli | Human | N-His-GST&C-Myc | 722-847aa |
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| SPINK5-5582H | Recombinant Human SPINK5 Protein (Gly699-Ser830), N-His tagged | E.coli | Human | His | Gly699-Ser830 |
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Involved Pathway
SPINK5 involved in several pathways and played different roles in them. We selected most pathways SPINK5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPINK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SPINK5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SPINK5 itself. We selected most functions SPINK5 had, and list some proteins which have the same functions with SPINK5. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
SPINK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPINK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPINK5.
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References
- Aizawa, S; Ochiai, T; et al. Heterogeneous and abnormal localization of desmosomal proteins in oral intraepithelial neoplasms. JOURNAL OF ORAL SCIENCE 56:209-214(2014).
- Fortugno, P; Bresciani, A; et al. Proteolytic Activation Cascade of the Netherton Syndrome-Defective Protein, LEKTI, in the Epidermis: Implications for Skin Homeostasis. JOURNAL OF INVESTIGATIVE DERMATOLOGY 131:2223-2232(2011).
