SPG20
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Official Full Name
spastic paraplegia 20 (Troyer syndrome) -
Overview
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). -
Synonyms
SPG20;spastic paraplegia 20 (Troyer syndrome);spartin;KIAA0610;TAHCCP1;trans-activated by hepatitis C virus core protein 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPG20-2900H | Recombinant Human SPG20, GST-tagged | E.coli | Human | GST | 1-350aa | |
| SPG20-1519HCL | Recombinant Human SPG20 293 Cell Lysate | HEK293 | Human | Non |
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| Spg20-6090M | Recombinant Mouse Spg20 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
SPG20 involved in several pathways and played different roles in them. We selected most pathways SPG20 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPG20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | SH3GL3A,HSP70,HRAS,HSPA1B,DNM1B,ARF6A,SPG20A,RAB5B,TGFBR1A,CAPZB |
Protein Function
SPG20 has several biochemical functions, for example, protein binding,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPG20 itself. We selected most functions SPG20 had, and list some proteins which have the same functions with SPG20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NLRC5,LRRC75A-AS1,SVIP,ARMCX5-GPRASP2,MYO5B,DTNBP1,APBA3,PLEKHH2,CHID1,PDE9A |
| ubiquitin protein ligase binding | NDUFS2,CKB,CUL1B,EGFR,UBXN1,SQSTM1,UBE2K,XRCC5,HSPD1,PER1 |
Interacting Protein
SPG20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPG20 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPG20.
HSPA5;NCL;HSPA9;Map3k1;HTT;SMAD2;ZFYVE9;papC;cpxR;SMURF2;APPL1;SEC16A;ACSL4;ACSL3;AIFM1;VIM;UBB
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References
- Robay, D; Patel, H; et al. Endogenous spartin, mutated in hereditary spastic paraplegia, has a complex subcellular localization suggesting diverse roles in neurons. EXPERIMENTAL CELL RESEARCH 312:2764-2777(2006).
- Lu, J; Rashid, F; et al. The hereditary spastic paraplegia protein spartin localises to mitochondria. JOURNAL OF NEUROCHEMISTRY 98:1908-1919(2006).
- Bakowska, JC; Jenkins, R; et al. The Troyer syndrome (SPG20) protein spartin interacts with Eps15. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334:1042-1048(2005).
