SPDEF
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Official Full Name
SAM pointed domain containing ets transcription factor -
Overview
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SPDEF;SAM pointed domain containing ets transcription factor;SAM pointed domain-containing Ets transcription factor;bA375E1.3;PDEF;Prostate derived Ets factor;PROSTATE EPITHELIUM SPECIFIC ETS TRANSCRIPTION FACTOR;Prostate specific Ets;PSE;RP11-375E1__A.3;OTTHUMP00000016234;prostate-specific Ets;prostate-derived Ets factor;prostate epithelium-specific Ets transcription factor
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPDEF-1524HCL | Recombinant Human SPDEF 293 Cell Lysate | HEK293 | Human | Non |
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| SPDEF-1429HFL | Recombinant Full Length Human SPDEF Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| SPDEF-2083H | Recombinant Human SPDEF Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SPDEF-2083H-B | Recombinant Human SPDEF Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Spdef-6088M | Recombinant Mouse Spdef Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| SPDEF-643H | Recombinant Human SPDEF Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
SPDEF involved in several pathways and played different roles in them. We selected most pathways SPDEF participated on our site, such as Regulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPDEF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Androgen receptor activity | HOXB13,SMARCA2,TRIM24,NR2C1,NR2C2,NR0B1,SRY,APPBP2,KAT7,SMARCE1 |
Protein Function
SPDEF has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPDEF itself. We selected most functions SPDEF had, and list some proteins which have the same functions with SPDEF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXO3,FOXR1,TFAP2D,RUNX3,FOXG1C,AHR2,FOXJ1B,FOXO1B,NPAS4A,ETV5A |
| sequence-specific DNA binding | POU1F1,ESRRGB,ENG2B,CREB3L3A,HOXD12A,HOXC12A,NR1D2A,ASCL1A,NR2F2,POU3F2A |
Interacting Protein
SPDEF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPDEF here. Most of them are supplied by our site. Hope this information will be useful for your research of SPDEF.
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