SOX5

  • Official Full Name

    SRY (sex determining region Y)-box 5

  • Overview

    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

  • Synonyms

    SOX5;SRY (sex determining region Y)-box 5;transcription factor SOX-5;L SOX5;MGC35153;Sex determining region Y box 5;SOX 5;SOX 5 protein;SOX5 protein;SOX5_HUMAN;SRY (sex determining region Y) box 5;SRY box 5;Transcription factor SOX 5;Transcription factor SOX5;OTTHUMP00000239955;OTTHUMP00000239958;OTTHUMP00000239959;OTTHUMP00000239960;OTTHUMP00000239961;OTTHUMP00000239962;OTTHUMP00000239963;L-SOX5

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • His
  • Flag
  • His&T7
  • Non
  • DDK&Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SOX5-2884H Recombinant Human SOX5, His-tagged E.coli Human His C-term-375aa
SOX5-107H Recombinant Human SOX5 Protein, DDK-tagged Sf9 Cells Human Flag
SOX5-1204C Recombinant Chicken SOX5 Mammalian Cells Chicken His
SOX5-143H Recombinant Human SOX5 protein, T7/His-tagged E.coli Human His&T7 762 a.a.
SOX5-30693TH Recombinant Human SOX5, His-tagged E.coli Human His 280-516 a.a.
SOX5-3397Z Recombinant Zebrafish SOX5 Mammalian Cells Zebrafish His
SOX5-1558HCL Recombinant Human SOX5 293 Cell Lysate HEK293 Human Non
SOX5-2720H Recombinant Human SOX5 Protein, His-tagged E.coli Human His Met1-Pro284
Sox5-6057M Recombinant Mouse Sox5 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
SOX5-6337H Recombinant Human SOX5 Protein (Met14-Pro284), N-His tagged E.coli Human His Met14-Pro284
SOX5-659H Recombinant Human SOX5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc

    Involved Pathway

    SOX5 involved in several pathways and played different roles in them. We selected most pathways SOX5 participated on our site, such as Endochondral Ossification,Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endochondral Ossification RUNX3,IFT88,PTH,COL2A1,CST5,RUNX2A,DDR2,COL10A1A,ADAMTS5,SERPINH1
    Neural Crest Differentiation TBX6,OLIG1,LHX1,HEY2,DMBX1,OLIG2,ZIC1,TCF4,GBX2,CDH7

    Protein Function

    SOX5 has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX5 itself. We selected most functions SOX5 had, and list some proteins which have the same functions with SOX5. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding YBX1,TFAM,FOXP2,NR2F5,KLF3,ZNF274,RBPJL,HOMEZA,ZNF436,FLI1B
    protein heterodimerization activity ITGA3,TAF13,HIST1H3G,H2BFWT,H3F3B.1,MTTP,IRAK3,BARD1,CD3E,HIST1H3A
    transcription regulatory region DNA binding FOXM1,CCNT1,H2AFY,ZFP746,FOS,WNT11,ZFP513,PAX8,TRP63,KLF4
    protein binding CKM,MRC1,HPCAL1,TNIP1,DCSTAMP,EIF3I,CENPW,LAMP2,CRB1,HOXD12
    RNA polymerase II transcription factor activity, sequence-specific DNA binding LYL1,JUN,SOX21A,HIF3A,NPAS4,ETV4,ZNF488,RUNX2A,ELK4,SIM1A

    Interacting Protein

    SOX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX5.

    ARID5A;g2xkq0_human;CRX;tax;LMO2;LMO1;PRR20C

    Resources

    Research Area

    Chondrogenesis Markers
    Transcription Factors in the Akt Pathway
    Neural Stem Cell Transcription Factors

    References

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