SOX3
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Official Full Name
SRY (sex determining region Y)-box 3 -
Overview
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency. -
Synonyms
SOX3;SRY (sex determining region Y)-box 3;panhypopituitarism , PHP;transcription factor SOX-3;PHP;GHDX;MRGH;PHPX;SOXB
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SOX3-226Z | Recombinant Zebrafish SOX3 | Mammalian Cells | Zebrafish | His |
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| SOX3-4415R | Recombinant Rhesus monkey SOX3 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| SOX3-5769C | Recombinant Chicken SOX3 | Mammalian Cells | Chicken | His |
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| SOX3-4231R | Recombinant Rhesus Macaque SOX3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SOX3-4231R-B | Recombinant Rhesus Macaque SOX3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
SOX3 involved in several pathways and played different roles in them. We selected most pathways SOX3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SOX3 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX3 itself. We selected most functions SOX3 had, and list some proteins which have the same functions with SOX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | RELB,HOXC4,ZKSCAN4,GLIS2,RARAB,ETV1,ZFP37,ZNF571,ZRANB2,FOXD3 |
| DNA binding | SOX1B,ZNF48,FOXB1A,HIST1H4F,ZNF155,ZNF446,ZHX1,HOXB2A,EXO1,ZNF43 |
| RNA polymerase II transcription corepressor activity | N4BP2L2,TBX18,TBX15,SIN3A,UXT,URI1,ELANE,TLE1,CTBP1,HDAC1 |
| RNA polymerase II core promoter sequence-specific DNA binding | SPI1,NR4A2,ZNF277,MTF1,TRP53,SFPI1,SP3,GBX2,GATA6,NLRC5 |
Interacting Protein
SOX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX3.
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References
- Rogers, N; Cheah, PS; et al. Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis. GENE EXPRESSION PATTERNS 13:240-248(2013).
- Hosoya, A; Kwak, S; et al. Immunohistochemical Localization of Cytokeratins in the Junctional Region of Ectoderm and Endoderm. ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY 293:1864-1872(2010).
