SOX13

  • Official Full Name

    SRY (sex determining region Y)-box 13

  • Overview

    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.

  • Synonyms

    SOX13;SRY (sex determining region Y)-box 13;transcription factor SOX-13;ICA12;islet cell 12;MGC117216;Sox 13;SRY box 13;SRY related HMG box gene 13;type 1 diabetes autoantigen;SRY-box 13;islet cell antigen 12;SRY-related HMG-box gene 13;type 1 diabetes autoantigen ICA12;Sox-13

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Flag
  • His&Fc&Avi
  • Myc&DDK

    Involved Pathway

    SOX13 involved in several pathways and played different roles in them. We selected most pathways SOX13 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Signal Transduction,Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Deactivation of the beta-catenin transactivating complex CBY1,TLE1,SOX6,RBBP5,BCL9,TLE3,SOX4A,PYGO2,C,SRY
    TCF dependent signaling in response to WNT RNF43,PYGO2,RYK,RSPO3,LGR4,DACT1,TNKS2,SOX4B,LGR6,BCL9L
    Signaling by Wnt KREMEN2,KREMEN1,RNF43,LGR6,SOX9A,WIF1,LGR5,WNT8-2,BCL9,RSPO2
    Signal Transduction USP15,KREMEN1,SOX7,EMR2,ARHGEF16,ARHGAP26,CDC73,CRABP2,STAM2,APOC2

    Protein Function

    SOX13 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX13 itself. We selected most functions SOX13 had, and list some proteins which have the same functions with SOX13. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding E4F1,EAF2,ETV5,RARG,BARHL1A,NHLH1,CEBPB,ZNF773,PHOX2B,CUX2
    transcription factor activity, sequence-specific DNA binding ZFP30,STAT1B,AHCTF1,FOXO1A,GCM1,NR1H5,NFKB1,SLC30A9,FOXP1A,ARNT
    sequence-specific DNA binding IRX6A,TBX5A,ATF5A,ATF7,EOMES,CAMTA2,BARHL1B,NR2F1A,FLI1A,LMX1A
    protein binding RPS6,MKRN1,SOX6,GRN,UBA1,RNF149,FBLIM1,ATF5,NTRK1,FAM115A

    Interacting Protein

    SOX13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX13 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX13.

    CTBP2;SMAD7;YTHDC1

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