SOCS1

  • Official Full Name

    suppressor of cytokine signaling 1

  • Overview

    This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

  • Synonyms

    SOCS1;suppressor of cytokine signaling 1;JAB;CIS1;SSI1;TIP3;CISH1;SSI-1;SOCS-1;TIP-3;JAK binding protein;JAK-binding protein;Tec-interacting protein 3;STAT induced SH3 protein 1;STAT-induced STAT inhibitor 1;cytokine-inducible SH2 protein 1

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cells
  • Yeast
  • His
  • DDK
  • Myc
  • Non
  • Avi
  • Fc
  • Flag

    Involved Pathway

    SOCS1 involved in several pathways and played different roles in them. We selected most pathways SOCS1 participated on our site, such as Ubiquitin mediated proteolysis,Osteoclast differentiation,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MicroRNAs in cancer STMN1,NOTCH2,MTOR,PRKCA,ATM,RPTOR,ABL1,CDCA5,UBE2I,EP300
    Osteoclast differentiation PIK3R3,LILRA4,TRAF6,NFKB1,MAPK9,TNFRSF11A,NCF4,MAPK12,IFNG,SFPI1
    Toxoplasmosis LAMB2,IKBKG,TLR2,GNAI1,HLA-DRB3,CASP8,MAPK11,IL10RB,IL12B,LAMA2
    Jak-STAT signaling pathway CRFB4,IL6,Gh,AKT3A,Il4ra,IL28A,IL2RB,SOCS7,SOCS2,STAT5B
    Type II diabetes mellitus PRKCZ,IRS2,PIK3R2,MAPK1,PIK3R3,ADIPOQ,INS2,PIK3R1,SOCS4,MAPK3
    Ubiquitin mediated proteolysis FZR1A,SKP2,UBE4A,SKP1,RFWD2,SMURF2,CUL4A,CBLB,FBXW8,UBE2L3
    Insulin signaling pathway G6PCA.2,HRAS,PIK3CD,MAPK8,PRKAG2,PDE3B,EXOC7,FBP1B,PPP1CAB,GRB2B
    Prolactin signaling pathway MAPK13,NFKB1,SHC3,ESR2,TNFRSF11A,MAP2K1,PPIB,AKT2,SHC1,FOXO3

    Protein Function

    SOCS1 has several biochemical functions, for example, insulin-like growth factor receptor binding,kinase inhibitor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS1 itself. We selected most functions SOCS1 had, and list some proteins which have the same functions with SOCS1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding DHX40,STOML1,TTC25,ELF2,AHI1,SHE,AXL,PTTG1,CIR1,PIK3IP1
    protein kinase inhibitor activity CHP1,PRKRIP1,GMFG,DUSP19,CHP,SOCS6B,SH3BP5B,SH3BP5,TAOK3,SOCS5B
    kinase inhibitor activity AHSG,LRP6,RHOH
    protein kinase binding STX1B,CASP9,PLK1S1,APC,FBXO5,GRB7,ACTA2,TEX14,NEFH,CDKN2C
    insulin-like growth factor receptor binding INS,GNAS,Ren1,IGF2B,IGF3,IRS1,IGF1,PIK3R1,ARRB1,IGF2

    Interacting Protein

    SOCS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS1.

    TCEB1;COMMD1;PIK3R1;CRK;CRKL;ERBB2;MET;gag;RELA;JAK2;npm_alk

    SOCS1 Related Signal Pathway

    Resources

    Research Area

    Intracellular Signaling Molecules in Angiogenesis

    References

    • Sun, K; Salmon, S; et al. Expression of Suppressor of Cytokine Signaling 1 (SOCS1) Impairs Viral Clearance and Exacerbates Lung Injury during Influenza Infection. PLOS PATHOGENS 10:-(2014).
    • Disanto, G; Sandve, GK; et al. DNase hypersensitive sites and association with multiple sclerosis. HUMAN MOLECULAR GENETICS 23:942-948(2014).

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