SNX13
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Official Full Name
sorting nexin 13 -
Overview
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. -
Synonyms
SNX13;sorting nexin 13;sorting nexin-13;KIAA0713;RGS PX1;RGS domain and PHOX domain containing protein;rgs domain- and phox domain-containing protein;RGS-PX1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SNX13-3758C | Recombinant Chicken SNX13 | Mammalian Cell | Chicken | His |
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| SNX13-1600HCL | Recombinant Human SNX13 293 Cell Lysate | HEK293 | Human | Non |
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| SNX13-394H | Recombinant Human SNX13 Protein, His-tagged | E.coli | Human | His | Ala97~Asn284 |
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Involved Pathway
SNX13 involved in several pathways and played different roles in them. We selected most pathways SNX13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SNX13 has several biochemical functions, for example, phosphatidylinositol binding,phosphatidylinositol-3-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX13 itself. We selected most functions SNX13 had, and list some proteins which have the same functions with SNX13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol binding | HS1BP3,RPS6KC1,SH3PXD2A,PLD1,MYO1E,MTM1,ING2,SNX16,SNX7,PLD2 |
| phosphatidylinositol-3-phosphate binding | SNX27,WDR45,SESTD1,PHLDA3,WIPI2,PLEKHF1,LANCL2,ZFYVE19,BBS5,PARD3 |
Interacting Protein
SNX13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX13 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX13.
TDP2;G6PC;NR1I3;KLF15;pi3p
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References
- Li, J; Li, CM; et al. SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain. NATURE COMMUNICATIONS 5:-(2014).
- Angel, JM; Abel, EL; et al. Fine Mapping Reveals That Promotion Susceptibility Locus 1 (Psl1) Is a Compound Locus With Multiple Genes That Modify Susceptibility to Skin Tumor Development. G3-GENES GENOMES GENETICS 4:1071-1079(2014).
