SNW1

  • Official Full Name

    SNW domain containing 1

  • Overview

    This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.

  • Synonyms

    SNW1;SNW domain containing 1;SKI interacting protein , SKIIP;SNW domain-containing protein 1;Bx42;NCoA 62;Prp45;PRPF45;SKIP;Bx 42;Homolog of Drosophila BX42;MGC119379;Nuclear protein SkiP;Nuclear receptor coactivator 62 kD;Nuclear receptor coactivator NCoA 62;Nuclear receptor coactivator NCoA62;Prp 45;PRPF 45;Ski interacting protein;SKIIP;SNW 1;SNW domain containing protein 1;SNW1 protein;SKI-interacting protein;nuclear receptor coactivator, 62-kD;nuclear receptor coactivator NCoA-62;NCOA-62
Cat.# Product name Source (Host) Species Tag Protein Length Price
SNW1-29295TH Recombinant Human SNW1, His-tagged E.coli Human His 271-536 a.a.
SNW1-852Z Recombinant Zebrafish SNW1 Mammalian Cells Zebrafish His
SNW1-618HCL Recombinant Human SNW1 lysate HEK293 Human Non

    Involved Pathway

    SNW1 involved in several pathways and played different roles in them. We selected most pathways SNW1 participated on our site, such as Spliceosome,Notch signaling pathway,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNW1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epstein-Barr virus infection RELB,NFKB1,VIM,TP53,POLR2J,HLA-DRB4,NFKBIB,IKBKB,POLR3F,PSMD2
    Spliceosome SRSF7A,HNRNPM,TXNL4A,SRSF7B,HNRNPA1,SRSF6,HNRNPA1B,SRSF5B,CTNNBL1,SRSF1
    Viral carcinogenesis GTF2A2,HIST1H2BG,HDAC4,RBL1,PIK3CB,C3,GTF2H2C_2,GTF2H4,TRAF5,TRAF2
    Notch signaling pathway DLL3,DLA,DTX2,CTBP2,NOTCH1B,DVL3A,PSEN1,PSENEN,PTCRA,JAG1A

    Protein Function

    SNW1 has several biochemical functions, for example, Notch binding,SMAD binding,nuclear hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNW1 itself. We selected most functions SNW1 had, and list some proteins which have the same functions with SNW1. You can find most of the proteins on our site.

    Function Related Protein
    transcription coactivator activity NPM1,NFYC,CITED4,TAF9,RFXAP,SUB1B,NFE2,MYSM1,ESR2,HCFC1
    Notch binding DLL4,DLL3,HIF1AN,JAG1B,AAK1,JAG2,NOTCH4,C8orf4,EGFL7,NOTCH1
    nuclear hormone receptor binding MED1,NCOA3,SIRT1,TACC2,MYOD1,Ankar,NCOA2,TCF7L2,CRY1,CRX
    transcription corepressor activity HOMEZA,YAF2,HIF3A,TMEM38A,TDP2,NR2F2,RELB,SKI,ATF5,ZHX2
    retinoic acid receptor binding MED1,NSD1,LRIF1,RXRA,AASS,ACTN4,PRAMEF1,PRAMEF2,CTBP2,ASXL1
    poly(A) RNA binding SART3,CFAP20,NCBP1,SLBP,RPL27A,HMGB3,SAP18,RPL15,APEH,RBM22
    SMAD binding SMURF2,EID2,MEF2A,PURB,SKOR1A,BMPR1B,TGFBR1,MAGI2,SKIB,ACVR1B
    protein binding GABARAPL2,MPRIP,PODXL2,TAF1D,NITR9,GFM2,SLC14A2,ATP2B1,PKP1,CALU
    vitamin D receptor binding MED24,TAF11,MED14,MED1,RXRA,THRAP3,MED17,MED16,TAF7,RUNX2B

    Interacting Protein

    SNW1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNW1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNW1.

    PPIL1;SNIP1;PABPN1

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