SNRNP35
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Official Full Name
small nuclear ribonucleoprotein 35kDa (U11/U12) -
Overview
The protein encoded by this gene is a homolog of U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal is rich in Arg/Asp and Arg/Glu dipeptides; a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. This gene is differentially expressed in a variety of human tissues. Alternative splicing results in multiple transcript variants encoding distinct proteins. -
Synonyms
HM-1;MGC138160;U1SNRNPBP;SNRNP35;U11/U12 small nuclear ribonucleoprotein 35 kDa protein;U11/U12-35K;protein HM-1;U11/U12 snRNP 35K;OTTHUMP00000236244;OTTHUMP00000236245;U11/U12 snRNP 35 kDa protein;U1 snRNP binding protein homolog;U1 snRNP-binding protein homolog;U1-snRNP binding protein homolog
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
SNRNP35 involved in several pathways and played different roles in them. We selected most pathways SNRNP35 participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNRNP35 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA Splicing | HNRNPA0,ZMAT5,CCAR1,HNRNPH1L,HNRNPA2B1,SNRNP25,HNRNPA0B,HNRNPL2,RBM5,RNPC3 |
| Gene Expression | AIMP1,SESN3,WARS2,EIF4H,ZNF669,DGCR8,SF3A3,CDK9,ESRRG,MED7 |
| Processing of Capped Intron-Containing Pre-mRNA | PTBP1B,HNRNPR,HNRNPA0B,CSTF1,PAPOLA,TTC6,HNRNPH1L,CD2BP2,SLBP,THOC4 |
| mRNA Splicing - Minor Pathway | SNRNP25,SF3B2,PRPF8,YBX1,PDCD7,SF3B4,SNRNP48,ZMAT5,RNPC3,TXNL4A |
Protein Function
SNRNP35 has several biochemical functions, for example, mRNA binding,nucleotide binding,snRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNRNP35 itself. We selected most functions SNRNP35 had, and list some proteins which have the same functions with SNRNP35. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mRNA binding | NANOS2,ZFP36,ESRP1,THOC2,MRPL13,RBM38,G3BP1,EIF4ENIF1,EIF4A1,RBMX |
| nucleotide binding | DDX39,RBMY1B,MKNK2A,ZFML,CLPXA,LARP6,TUBA8L3,NT5C2,SRSF5B,TMEM63B |
| snRNA binding | CDK9,CCNT1,HEXIM2,RBPMS,NCBP2,HEXIM1 |
Interacting Protein
SNRNP35 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNRNP35 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNRNP35.
SRPK2;TNFSF11;MAP4K2;ILK;TAB1;PTBP3
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References
- Stark, MR; Dunn, EA; et al. Dramatically reduced spliceosome in Cyanidioschyzon merolae. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E1191-E1200(2015).
- Ashour, J; Schmidt, FI; et al. Intracellular Expression of Camelid Single-Domain Antibodies Specific for Influenza Virus Nucleoprotein Uncovers Distinct Features of Its Nuclear Localization. JOURNAL OF VIROLOGY 89:2792-2800(2015).
