SLK
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Official Full Name
STE20-like kinase -
Overview
SLK and induces apoptosis in cultured fibroblasts. Over-expression of SLK in various cell lines induces rapid disassembly of actin stress fibers and cell death. Relatively high levels of SLK protein and activity have been observed in all cell types analyzed, suggesting a functional role for SLK in physiological processes other than apoptosis. Activity of SLK is also increased during progression through the G2 phase of the mammalian cell cycle and may function as a regulator of Plk during the somatic cell cycle. The activity of SLK is regulated by phosphorylation and its expression is down-regulated upon mitogen depletion of myoblast and fibroblast cultures. -
Synonyms
SLK;STE20-like kinase;SNF1 (sucrose nonfermenting, yeast, homolog) like kinase, SNF1 sucrose nonfermenting like kinase (yeast) , STE20 like kinase (yeast);STE20-like serine/threonine-protein kinase;KIAA0204;se20 9;STK2;hSLK;STE20-related kinase;Long Ste20-like Kinase;CTCL tumor antigen se20-9;serine/threonine-protein kinase 2;Ste20-related serine/threonine kinase;SNF1 sucrose nonfermenting like kinase;STE20-related serine/threonine-protein kinase;SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase;LOSK;se20-9;bA16H23.1;MGC133067
Recombinant Proteins
- Human
- Rat
- Pan paniscus
- Sf9 Cells
- Mammalian Cells
- HEK293
- Insect Cells
- Sf21 Cells
- Non
- GST
- His
- Avi&Fc&His
Involved Pathway
SLK involved in several pathways and played different roles in them. We selected most pathways SLK participated on our site, such as Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oocyte meiosis | PKMYT1,PPP2R5E,ANAPC1,YWHABL,PGR,PRKACG,CDC25C,SGOL1,SMC1B,YWHAZ |
Protein Function
SLK has several biochemical functions, for example, ATP binding,identical protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLK itself. We selected most functions SLK had, and list some proteins which have the same functions with SLK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | DDX1,GHR,ECE1,MFF,ERN1,TREX1,STK25,FAP,FLRT3,KCNH2 |
| protein serine/threonine kinase activity | SQSTM1,SGK2A,STK35,HIPK3,ZNF143B,TNNI3K,RIPK4,TP53RK,MYO3B,MAPK13 |
| ATP binding | ALDH18A1,ORC1L,SLC14A2,PBK,MAPK8,HLTF,PFAS,KIF25,NTRK2,MYO3B |
| identical protein binding | ACTG1,RB1,GRIK5,G6PD,SID4,MAP3K13,UBQLN1,FXR2,RASSF1,SRPX2 |
Interacting Protein
SLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLK here. Most of them are supplied by our site. Hope this information will be useful for your research of SLK.
KEAP1;IKBKE;CLSTN1;rpoB;q7cl54_yerpe;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;bosutinib;imatinib;purvalanol b;crizotinib;GABARAP
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References
- Leca, N; Warner, P; et al. Outcomes of Simultaneous Liver and Kidney Transplantation in Relation to a High Level of Preformed Donor-Specific Antibodies. TRANSPLANTATION 96:914-918(2013).
- Kressel, A; Therapondos, G; et al. Excellent liver retransplantation outcomes in hepatitis C-infected recipients. CLINICAL TRANSPLANTATION 27:E512-E520(2013).
