SLC6A12
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Official Full Name
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 -
Overview
SLC6A12, also known as BGT-1, is a member of the Na+ - and Cl- -dependent neurotransmitter transporter family. It transports both betaine and the neurotransmitter GABA at the blood-brain barrier as well as controls osmoregulation. This betaine/GABA transp -
Synonyms
SLC6A12;solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12;sodium- and chloride-dependent betaine transporter;BGT 1;gamma-aminobutyric acid transporter;Na(+)/Cl(-) betaine/GABA transporter;BGT1;GAT2;BGT-1;FLJ38727
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC6A12-2781H | Recombinant Human SLC6A12, His-tagged | E.coli | Human | His | 548-614aa | |
| SLC6A12-4303R | Recombinant Rhesus monkey SLC6A12 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| SLC6A12-5563R | Recombinant Rat SLC6A12 Protein | Mammalian Cells | Rat | His |
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| SLC6A12-4119R | Recombinant Rhesus Macaque SLC6A12 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SLC6A12-4119R-B | Recombinant Rhesus Macaque SLC6A12 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SLC6A12-5222R | Recombinant Rat SLC6A12 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC6A12-5222R-B | Recombinant Rat SLC6A12 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SLC6A12 involved in several pathways and played different roles in them. We selected most pathways SLC6A12 participated on our site, such as Amino acid transport across the plasma membrane,Creatine metabolism,GABA synthesis, release, reuptake and degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of amino acids and derivatives | SLC25A10,AMDHD1,SLC25A2,OAZ2B,IDO2,CTHL,OAZ2,CRYM,CKMB,IVD |
| Creatine metabolism | LSM1,CKB,SLC6A8,CKBA,CKM,CKMT1B,SLC6A7,CKMT2A,CKMT2,CKMB |
| Neuronal System | KCNA6,KCNG4A,CPLX1,SLC1A2B,KCNJ1A.4,PICK1,GJC1,KCNC4,PANX2,PANX1A |
| Amino acid transport across the plasma membrane | SLC6A18,SLC6A6A,SLC7A6,SLC1A4,SLC7A8A,SLC6A20B,SLC7A10,SLC6A19A,SLC43A2,SLC38A3 |
| Metabolism | CKMT2A,DGUOK,CYP2W1,AK7,SLC2A3,GLTP,THEM5,GLYATL1,CYP4F11,CYP2K16 |
| Metabolism of polyamines | CKMT2A,NAGS,AZIN2,OAZ3,SLC25A2,CKMB,LSM1,CKBA,OAZ1,AMD2 |
| GABA synthesis, release, reuptake and degradation | SYT1A,CPLX2L,SNAP25B,RAB3AA,SLC6A11,SNAP25A,CCDC167,CPLX1,SLC6A1A,SLC6A1B |
| Na+/Cl- dependent neurotransmitter transporters | SLC6A1A,SLC6A6,SLC6A19A,SLC6A15,SLC6A9,SLC6A1B,SLC6A7,SLC6A5,SLC6A11,SLC6A20 |
Protein Function
SLC6A12 has several biochemical functions, for example, gamma-aminobutyric acid:sodium symporter activity,neurotransmitter:sodium symporter activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A12 itself. We selected most functions SLC6A12 had, and list some proteins which have the same functions with SLC6A12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neurotransmitter:sodium symporter activity | SLC6A15,SLC6A11A,SLC6A1,SLC6A4A,SLC6A13L,SLC6A9,SLC6A20A,SLC6A19B,SLC6A17,SLC6A4B |
| protein binding | DZIP1L,CDK20,ANKRD49,DRD2,SHISA3,GNA13,SYCE1,CNOT4,NABP1,ZNF460 |
| gamma-aminobutyric acid:sodium symporter activity | SLC6A13,SLC6A13L,SLC6A11,SLC6A1,SLC6A11A,SLC6A1B,SLC6A1A |
Interacting Protein
SLC6A12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A12.
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References
- Holmseth, S; Zhou, Y; et al. Specificity Controls for Immunocytochemistry: The Antigen Preadsorption Test Can Lead to Inaccurate Assessment of Antibody Specificity. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:174-187(2012).
- Zhou, Y; Holmseth, S; et al. The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 302:F316-F328(2012).
- Zhou, Y; Holmseth, S; et al. EVIDENCE AGAINST A ROLE OF THE BETAINE-GABA TRANSPORTER (BGT1, SLC6A12) IN THE CONTROL OF GABA RECEPTOR ACTIVATION. GLIA 59:S69-S70(2011).
