SLC6A11
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Official Full Name
solute carrier family 6 (neurotransmitter transporter, GABA), member 11 -
Overview
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the;uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters,;such as SLC6A11 (Borden et al., 1994 (PubMed 7874447)). -
Synonyms
SLC6A11;solute carrier family 6 (neurotransmitter transporter, GABA), member 11;sodium- and chloride-dependent GABA transporter 3;GAT-3;GABA transporter GAT-3;solute carrier family 6 member 11;Gat3;Gabt4
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&Fc&Avi
- GST
Involved Pathway
SLC6A11 involved in several pathways and played different roles in them. We selected most pathways SLC6A11 participated on our site, such as GABA synthesis, release, reuptake and degradation,Na+/Cl- dependent neurotransmitter transporters,Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | KCNA2,ABCC9,KCNF1,KCNK6,BZRAP1,KCNH8,KCNJ1A.6,GABRR2A,KCNQ3,KCNC1 |
| Transmembrane transport of small molecules | SLC7A6,ABCA4A,CLCN6,ANO4,SLC27A4,SLC6A1A,AZGP1,SLC6A6A,SRI,SLC4A1A |
| GABA synthesis, release, reuptake and degradation | SLC6A1A,STXBP1A,CCDC167,SYT1A,SNAP25B,ABAT,SNAP25A,RAB3AA,CPLX1,SLC6A12 |
| Reuptake of GABA | SLC6A1B,SLC6A1A |
| SLC-mediated transmembrane transport | SLC22A15,SLC9A9,SLC6A20,SLC6A2,SLC28A2,SLC7A11,SLC26A7,SLC2A6,SLC5A8,SLC39A6 |
| Neurotransmitter Release Cycle | PPFIA2,BZRAP1,PPFIA4,SLC17A7A,SLC1A2B,SLC6A1A,LIN7A,SLC1A2A,GLS2B,SLC6A1B |
| Na+/Cl- dependent neurotransmitter transporters | SLC6A5,SLC6A20B,SLC6A7,SLC6A9,SLC6A19B,SLC6A2,SLC6A18,SLC6A1A,SLC6A6,SLC6A1B |
| Transmission across Chemical Synapses | Apba1,SYN3,CACNG2B,GRIP1,RERG,CAMKK1B,SLC1A2A,SLC1A7B,CPLX2L,CACNB4B |
Protein Function
SLC6A11 has several biochemical functions, for example, gamma-aminobutyric acid:sodium symporter activity,neurotransmitter binding,neurotransmitter:sodium symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A11 itself. We selected most functions SLC6A11 had, and list some proteins which have the same functions with SLC6A11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| gamma-aminobutyric acid:sodium symporter activity | SLC6A13L,SLC6A13,SLC6A1B,SLC6A12,SLC6A11A,SLC6A1A,SLC6A1 |
| symporter activity | SLC4A11,SLC38A2,SLC1A9,SLC38A1,SLC46A2,SLC24A2,SLC23A2,SLC6A4A,SLC22A18,SLC16A11 |
| neurotransmitter:sodium symporter activity | SLC6A18,SLC6A17,SLC6A11A,SLC6A8,SLC6A1B,SLC6A4A,SLC6A1A,SLC6A12,SLC6A6B,SLC6A1 |
| neurotransmitter binding | NIPSNAP1,SLC6A13,GRIN1,GRIN3B,GRIN2A |
Interacting Protein
SLC6A11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A11 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A11.
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References
- Ramirez, O; Olalde, I; et al. Analysis of structural diversity in wolf-like canids reveals post-domestication variants. BMC GENOMICS 15:-(2014).
- Dikow, N; Maas, B; et al. 3p25.3 Microdeletion of GABA Transporters SLC6A1 and SLC6A11 Results in Intellectual Disability, Epilepsy and Stereotypic Behavior. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:3061-3068(2014).
