SLC5A8
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Official Full Name
solute carrier family 5 (iodide transporter), member 8 -
Overview
SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 (PubMed 12107270)) and;monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 (PubMed 15322102)). In;kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and;maintenance of blood lactate levels (Thangaraju et al., 2006 (PubMed 16873376)). -
Synonyms
SLC5A8;solute carrier family 5 (iodide transporter), member 8;sodium-coupled monocarboxylate transporter 1;AIT;Apical iodide transporter;Electrogenic sodium monocarboxylate cotransporter;MGC125354;SC5A8_HUMAN;SMCT;SMCT1;sodium coupled monocarboxylate transporter 1;Sodium iodide related cotransporter;Sodium iodide-related cotransporter;solute carrier family 5 iodide transporter member 8;Solute carrier family 5 member 8
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC5A8-15489M | Recombinant Mouse SLC5A8 Protein | Mammalian Cells | Mouse | His |
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| SLC5A8-8401M | Recombinant Mouse SLC5A8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC5A8-8401M-B | Recombinant Mouse SLC5A8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC5A8 involved in several pathways and played different roles in them. We selected most pathways SLC5A8 participated on our site, such as Organic anion transporters,SLC-mediated transmembrane transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC5A8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SLC-mediated transmembrane transport | SLC35B4,SLC6A19A,SLC30A3,SLC12A4,SLC1A2B,SLC5A11,LCN15,SLC7A8A,SLC4A1A,SLC35D2 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | SLC20A1B,SLC6A20A,SLC20A1A,SLC3A2A,SLC7A3A,SLC6A20,SLC34A2A,SLC7A6,SLC4A4A,SLC24A4A |
| Organic anion transporters | SLC17A1,SLC25A10,SLC17A7A |
| Transmembrane transport of small molecules | ANO10A,AQP3B,GSDMA2,SLC29A1A,SLC9A5,SLC5A6B,FXYD6-FXYD2,CLCN6,SLC6A20A,SLC2A12 |
Protein Function
SLC5A8 has several biochemical functions, for example, symporter activity,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC5A8 itself. We selected most functions SLC5A8 had, and list some proteins which have the same functions with SLC5A8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| symporter activity | SLC17A8,SLC17A7,SLC16A2,SLC16A13,SLC6A20B,SLC16A4,SLC6A11A,SLC4A11,SLC24A2,SLC6A19B |
| transporter activity | RBP5,Abca2,MIPA,APODA.1,SEC22A,AQP3B,SLCO4C1,ABCB1,AP1B1,AP3S1 |
Interacting Protein
SLC5A8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC5A8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC5A8.
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References
- Helm, J; Coppola, D; et al. SLC5A8 Nuclear Translocation and Loss of Expression are Associated With Poor Outcome in Pancreatic Ductal Adenocarcinoma. PANCREAS 41:904-909(2012).
- Gopal, E; Umapathy, NS; et al. Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1768:2690-2697(2007).
- Gopal, E; Miyauchi, S; et al. Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 292:G402-G408(2007).
