SLC36A2
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Official Full Name
solute carrier family 36 (proton/amino acid symporter), member 2 -
Overview
This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. -
Synonyms
SLC36A2;solute carrier family 36 (proton/amino acid symporter), member 2;proton-coupled amino acid transporter 2;PAT2;TRAMD1;tramdorin;MGC119660;A530067G19Rik;FLJ16051;MGC119658;Proton coupled amino acid transporter 2;Proton/amino acid transporter 2;Solute carrier family 36 (proton/amino acid symporter) member 2;Solute carrier family 36 member 2;Tramdorin 1;tramdorin-1;OTTHUMP00000160624;OTTHUMP00000224111
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC36A2-2755H | Recombinant Human SLC36A2, His-tagged | E.coli | Human | His | 1-70aa | |
| SLC36A2-15412M | Recombinant Mouse SLC36A2 Protein | Mammalian Cells | Mouse | His |
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| SLC36A2-5521R | Recombinant Rat SLC36A2 Protein | Mammalian Cells | Rat | His |
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| SLC36A2-5180R | Recombinant Rat SLC36A2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| SLC36A2-5180R-B | Recombinant Rat SLC36A2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SLC36A2-8346M | Recombinant Mouse SLC36A2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| SLC36A2-8346M-B | Recombinant Mouse SLC36A2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC36A2 involved in several pathways and played different roles in them. We selected most pathways SLC36A2 participated on our site, such as Amino acid transport across the plasma membrane,Proton-coupled neutral amino acid transporters,SLC-mediated transmembrane transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC36A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SLC-mediated transmembrane transport | PDZD11,SLC2A15A,SLC4A2B,SLC30A2,LCN12,SLC30A6,SLC7A3,SLC2A7,SLC6A20B,SLC9A3.1 |
| Transmembrane transport of small molecules | SLC39A2,TRPM4C,SLC13A4,SLC26A3.1,SLC28A1,SLC30A8,RHAG,CUTC,SLC1A7A,SLC39A1 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | SLC1A7A,SLC43A2A,SLC38A4,SLC9A3.2,SLC12A1,SLC6A20B,SLC9A6A,SLC26A3.1,SLC20A2,SLC9A6B |
| Amino acid transport across the plasma membrane | SLC7A11,SLC3A2A,SLC6A6A,SLC7A3A,SLC7A3,SLC7A6,SLC6A19B,SLC6A6,SLC1A4,SLC7A8A |
Protein Function
SLC36A2 has several biochemical functions, for example, L-alanine transmembrane transporter activity,L-proline transmembrane transporter activity,glycine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC36A2 itself. We selected most functions SLC36A2 had, and list some proteins which have the same functions with SLC36A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrogen ion transmembrane transporter activity | Atp5k,ATP6V0D2,SLC36A3,ATP5G1,ATP6V0CA,ATP5IA,ATPV0E2,SLC36A1,SLC46A1,ATP6V0A1A |
| hydrogen:amino acid symporter activity | SLC36A3,SLC36A1 |
| L-alanine transmembrane transporter activity | SLC36A4,SLC36A1,SLC38A7,SLC1A4,SLC36A3,SLC38A3 |
| L-proline transmembrane transporter activity | SLC36A1,SLC1A4,SLC6A20A,SLC6A7,SLC36A3,SLC36A4 |
| glycine transmembrane transporter activity | SLC38A5,SLC36A1,SLC36A3,SLC38A5B |
Interacting Protein
SLC36A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC36A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC36A2.
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References
- Zebisch, K; Brandsch, M; et al. Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells. AMINO ACIDS 44:373-381(2013).
- Schioth, HB; Roshanbin, S; et al. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. MOLECULAR ASPECTS OF MEDICINE 34:571-585(2013).
