SLC30A8
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Official Full Name
solute carrier family 30 (zinc transporter), member 8 -
Overview
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SLC30A8;solute carrier family 30 (zinc transporter), member 8;zinc transporter 8;Solute carrier family 30 member 8;zinc transporter ZnT-8;ZnT-8;ZNT8;ZNT8_HUMAN
Recombinant Proteins
- Human
- Mouse
- Rat
- Xenopus laevis
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mus musculus
- Sf9 Cells
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- His
- SUMO
- Non
- Flag
- MBP
- GST
- Avi
- Fc
- Myc
Involved Pathway
SLC30A8 involved in several pathways and played different roles in them. We selected most pathways SLC30A8 participated on our site, such as Insulin processing,Metabolism of proteins,Metal ion SLC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC30A8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Zinc efflux and compartmentalization by the SLC30 family | SLC30A3,SLC30A5,SLC30A2,SLC30A6,SLC30A1A,SLC30A1B |
| Transmembrane transport of small molecules | ATP1A1A.3,BEST4,SLC1A3B,ABCA4A,MCOLN2,SLC17A1,EPB49,ANO5,TRPM4A,CLCN1 |
| Peptide hormone metabolism | CPA3,SLC30A6,MBOAT4,ATP6AP2,CGB7,CDX2,ACE,SLC38A8,PCSK2,O3far1 |
| SLC-mediated transmembrane transport | SLC13A4,LCN12,SLC6A1A,SLC35A3,SLC6A20,SLC6A9,RHCGL1,SLC6A1B,SLC35A3A,SLC30A6 |
| Insulin processing | EXOC8,PCSK2,CPN1,CPE,KIF5A,EXOC3,EXOC1,SLC30A6,RAB27A,PCSK1 |
| Metabolism of proteins | TIMM44,LMAN2L,NAT8B,ANKRD28,SEMG1,TRAPPC5,TIMM8A,CNIH2,MUC15,NOP56 |
| Metal ion SLC transporters | SLC30A6,SLC39A14,SLC39A7,SLC39A5,SLC39A8,CP,SLC39A1,SLC30A1A,SLC30A1B,SLC41A1 |
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | SLC39A7,SLC22A16,SLC2A13,SLC5A11,SLC6A5,SLC6A20B,RHCGA,SLC13A5,SLC5A3A,RHCGB |
Protein Function
SLC30A8 has several biochemical functions, for example, protein binding,protein homodimerization activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC30A8 itself. We selected most functions SLC30A8 had, and list some proteins which have the same functions with SLC30A8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BLOC1S1,EIF2A,FOXL2,FAM110A,LCMT2,BDKRB2,TRPV6,SPSB3,NUDT21,ANKRD1 |
| zinc ion transmembrane transporter activity | SLC39A14,SLC39A7,SLC11A2,SLC39A13,SLC30A7,SLC39A6,SLC39A12,SLC30A2,SLC30A10,SLC39A3 |
| zinc ion binding | LIMS2,PIAS4B,TRIM64C,MLL1,CREBBP,KDM5D,MYT1,APOBEC3B,ADAMTS1,ADAM5 |
| protein homodimerization activity | GRPEL1,SNX1,GSS,GNPTG,IL6ST,CAMK2B,ATG7,ERN1,TCF3A,MYH7 |
Interacting Protein
SLC30A8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC30A8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC30A8.
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References
- Araujo, DB; Skarstrand, H; et al. Zinc transporter 8 autoantibodies in patients with type 1 diabetes from a multiethnic population and their first degree relatives. ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA 58:737-743(2014).
- Nayak, DK; Calderon, B; et al. ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions. DIABETES 63:3438-3448(2014).
