SLC2A10
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Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 10 -
Overview
Glucose transporters (GLUT or SLC2A family) are a family of membrane proteins found in most mammalian cells. GLUTs are integral membrane proteins that contain 12 membrane-spanning helices with both the amino and carboxyl termini exposed on the cytoplasmic side of the plasma membrane. GLUT proteins transport glucose and related hexoses according to a model of alternate conformation, which predicts that the transporter exposes a single substrate binding site toward either the outside or the inside of the cell. Binding of glucose to one site provokes a conformational change associated with transport, and releases glucose to the other side of the membrane. The inner and outer glucose-binding sites are, it seems, located in transmembrane segments 9, 10, 11; also, the QLS motif located in the seventh transmembrane segment could be involved in the selection and affinity of transported substrate. -
Synonyms
SLC2A10;solute carrier family 2 (facilitated glucose transporter), member 10;ATS;GLUT10;MGC126706;solute carrier family 2, facilitated glucose transporter member 10
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC2A10-2742H | Recombinant Human SLC2A10, GST-tagged | E.coli | Human | GST | 310-426aa | |
| SLC2A10-6231Z | Recombinant Zebrafish SLC2A10 | Mammalian Cell | Zebrafish | His |
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| SLC2A10-0477H | Recombinant Human SLC2A10 Protein (G2-S541), 8×His-MBP, Flag tagged | Insect Cell | Human | His&Flag&MBP | G2-S541 |
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Involved Pathway
SLC2A10 involved in several pathways and played different roles in them. We selected most pathways SLC2A10 participated on our site, such as Facilitative Na+-independent glucose transporters,SLC-mediated transmembrane transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC2A10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | RHBG,RHCGB,CP,SLC2A13B,SLC13A5,SLC39A6,SLC6A19B,SLC6A2,RHCGL1,MATE4 |
| SLC-mediated transmembrane transport | LCN9,SLC39A6,SLC44A5B,SLC26A3.2,SLC5A9,SLC39A8,SLC6A15,SLC15A3,SLC26A3,SLC39A2 |
| Facilitative Na+-independent glucose transporters | SLC2A7,SLC2A6,SLC2A15A,SLC2A15B,SLC2A12,SLC2A8,SLC2A3 |
| Transmembrane transport of small molecules | SLC1A4,SLC5A4,SLC2A7,SLC1A7A,AQP3A,SLC6A7,SGK2,SLC20A1,AQP9B,GSDMA2 |
Protein Function
SLC2A10 has several biochemical functions, for example, sugar:proton symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC2A10 itself. We selected most functions SLC2A10 had, and list some proteins which have the same functions with SLC2A10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sugar:proton symporter activity | SLC2A15A,SLC2A1A,SLC35A5,SLC2A15B,SLC35A4,SLC2A9L1,SLC35A2,SLC2A11B,SLC35A3B,SLC35A1 |
Interacting Protein
SLC2A10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC2A10 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC2A10.
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References
- Gatza, ML; Silva, GO; et al. An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer. NATURE GENETICS 46:1051-1059(2014).
- Ritelli, M; Chiarelli, N; et al. Arterial Tortuosity Syndrome: homozygosity for two novel and one recurrent SLC2A10 missense mutations in three families with severe cardiopulmonary complications in infancy and a literature review. BMC MEDICAL GENETICS 15:-(2014).
