SLC25A4
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Official Full Name
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -
Overview
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. -
Synonyms
SLC25A4;solute carrier family 25 (mitochondrial carrier;adenine nucleotide translocator), member 4;ANT1, PEO2, PEO3;ADP/ATP translocase 1;T1;ANT 1;ADP,ATP carrier protein 1;solute carrier family 25 member 4;heart/skeletal muscle ATP/ADP transloca
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Bovine
- Rhesus macaque
- Rat
- Oryctolagus cuniculus
- Mus musculus
- E.coli
- HEK293
- Mammalian Cells
- E.Coli/Yeast
- His
- Non
- Avi
- Fc
Involved Pathway
SLC25A4 involved in several pathways and played different roles in them. We selected most pathways SLC25A4 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC25A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | DNAL1,VDAC1,ITPR1,DCTN1,DCTN4,POLR2C,POLR2G,COX6C,HTT,NDUFA3 |
| HTLV-I infection | PPP3CB,ITGB2L,BCL2L1,HLA-G,CANX,Pdgfa&Pdgfb,ETS2,CD3G,LTA,CCND3 |
| cGMP-PKG signaling pathway | IRS4,ATP2A2,PRKG1,AGTR1A,ATF4,ROCK1,CALM1,MEF2A,GATA4,CALML3 |
| Parkinsons disease | NDUFV1,COX7A1,COX6A2,CYCS,MT-ND4,PRKACA,SDHC,UQCR11,NDUFA1,UBA1 |
| Calcium signaling pathway | PPP3CCA,ERBB3B,GNA11B,ADRB3,CALML5,EDNRAA,CAMK4,CACNA1SA,EDNRB2,CACNA1C |
Protein Function
SLC25A4 has several biochemical functions, for example, adenine transmembrane transporter activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC25A4 itself. We selected most functions SLC25A4 had, and list some proteins which have the same functions with SLC25A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adenine transmembrane transporter activity | SLC25A5 |
| protein binding | RRAS2,SRC,C11orf67,TACR1,INHBB,SYCP1,CD14,RAP1A,TBX5,HOXA1 |
Interacting Protein
SLC25A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC25A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC25A4.
LRRK2;BCL2L13;TNFRSF1B;AR;q5nfy6_fratt;E2F3;Smad6;NS;PCNT;NS;M1;GRB2;a52_vaccw;ICT1
Resources
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References
- Di Noia, MA; Todisco, S; et al. The Human SLC25A33 and SLC25A36 Genes of Solute Carrier Family 25 Encode Two Mitochondrial Pyrimidine Nucleotide Transporters. JOURNAL OF BIOLOGICAL CHEMISTRY 289:33137-33148(2014).
- Porcelli, V; Fiermonte, G; et al. The Human Gene SLC25A29, of Solute Carrier Family 25, Encodes a Mitochondrial Transporter of Basic Amino Acids. JOURNAL OF BIOLOGICAL CHEMISTRY 289:13374-13384(2014).
