SLC25A13
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Official Full Name
solute carrier family 25, member 13 (citrin) -
Overview
This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SLC25A13;solute carrier family 25, member 13 (citrin);CTLN2;calcium-binding mitochondrial carrier protein Aralar2;ARALAR2;CITRIN;mitochondrial aspartate glutamate carrier 2;AI785475;Calcium binding mitochondrial carrier protein Aralar2;Ctrn;RGD1565889;Solute carrier family 25 (citrin) member 13;Solute carrier family 25 member 13 (citrin);Solute carrier family 25 member 13;OTTHUMP00000024692
Recombinant Proteins
- Chicken
- Human
- Cynomolgus
- Macaca fascicularis
- Mus musculus
- Mammalian Cell
- E.coli
- E.coli expression system
- Insect Cell
- HEK293
- His
- Non
- His&Flag&MBP
- His&Fc&Avi
Involved Pathway
SLC25A13 involved in several pathways and played different roles in them. We selected most pathways SLC25A13 participated on our site, such as Gluconeogenesis,Glucose metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC25A13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | TIMM23,TIMM13,ADAMTSL4,CCDC59,ADD1,SMC5,CTDSP2,GRPEL1,TUBA1B,ADAMTSL5 |
| Metabolism | ADSS,UCP3,INSIG2,AZIN2,ACOT11B,SPTLC1,AHCY,ALOX5B.2,CHST14,AWAT1 |
| Glucose metabolism | SLC25A1,SLC25A11,SLC25A12,PFKLB,AGL,PYGMB,GYG1B,GYG2,GYG1A,SLC25A10 |
| Metabolism of carbohydrates | SLC26A1,HAS3,SLC5A9,HAS1,CHP,SLC25A10,CHST14,SLC25A11,GLB1L,LYVE1 |
| Mitochondrial protein import | PAM16,TIMM22,GFER,LDHD,PMPCB,GRPEL1,TIMM9,COX17,CHCHD4,SAMM50 |
| Gluconeogenesis | SLC25A1,SLC25A1A,SLC25A11,SLC25A10,GPR19,SLC25A12 |
Protein Function
SLC25A13 has several biochemical functions, for example, L-aspartate transmembrane transporter activity,L-glutamate transmembrane transporter activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC25A13 itself. We selected most functions SLC25A13 had, and list some proteins which have the same functions with SLC25A13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDH11Y,PGS1,EHD1,MMP19,SULF2B,CDH10A,PLA2G10,EFHC1,PVALB5,MELK |
| L-glutamate transmembrane transporter activity | SLC17A8,SLC38A7,SLC25A22,SLC1A7,SLC1A2,SLC1A6,SLC17A6A,SLC1A1,SLC25A12,SLC17A6 |
| L-aspartate transmembrane transporter activity | SLC1A6,SLC38A7,SLC25A12,SLC13A3 |
| transporter activity | CPNE3,ATP5O,SLC13A5,Slc4a2,SLC2A15A,RBP1,SLC4A11,SLC26A3,PTGDS,SLCO1F3 |
Interacting Protein
SLC25A13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC25A13 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC25A13.
USP50;BABAM1;BRE;15-deoxy-delta(12,14;NDUFA4;IKBKB;XRCC3;SCO1;MT-CO2;MT-CO3;MYC;ALB;Tuba3a;COX6C;ARAF;COX4I1;RNH1;COX7A2;COX6B1;ATF2
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