SLC24A4
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Official Full Name
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -
Overview
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants. -
Synonyms
SLC24A4;solute carrier family 24 (sodium/potassium/calcium exchanger), member 4;sodium/potassium/calcium exchanger 4;NCKX4;Na(+)/K(+)/Ca(2+)-exchange protein 4;NCKX4_HUMAN;Solute carrier family 24 member 4;SHEP6;SLC24A2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC24A4-15291M | Recombinant Mouse SLC24A4 Protein | Mammalian Cells | Mouse | His |
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| SLC24A4-1296H | Recombinant Human SLC24A4 Protein (A2-D622), 8×His-MBP, Flag tagged | Insect Cells | Human | His&Flag&MBP | A2-D622 |
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| SLC24A4-8268M | Recombinant Mouse SLC24A4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC24A4-8268M-B | Recombinant Mouse SLC24A4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC24A4 involved in several pathways and played different roles in them. We selected most pathways SLC24A4 participated on our site, such as Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC24A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Olfactory transduction | OR2L5,OR56A1,OR7C1,OR51B2,OLFR481,CAMK2A,OR6K3,OLFR494,OLFR1440,CAMK2G |
Protein Function
SLC24A4 has several biochemical functions, for example, antiporter activity,calcium channel activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC24A4 itself. We selected most functions SLC24A4 had, and list some proteins which have the same functions with SLC24A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium channel activity | TRPC2B,TRPM6,RYR1,CHRNA10,TRPC3,TRPV2,SLC24A2,CACNG1A,TRPC2,CACNA1SB |
| potassium ion binding | PKM2,KCNA4,PKM,SLC24A4A,SLC24A5,ATP1A1,PKMA,KCNJ11,SLC24A2,PKMB |
| calcium, potassium:sodium antiporter activity | SLC24A1,SLC24A2,SLC24A5,SLC24A4A |
| calcium ion binding | CD93,PPP3CA,CDH12,MAN1A2,CALML4A,PCDH2G2,CDH2,TMEM8C,CALM,SYT10 |
| sodium ion binding | SLC24A4A,ATP1A1,SLC24A2,PDXK,SLC34A2,SLC24A1,SLC24A5,CAPN3,SCN9A |
| antiporter activity | SLC7A5,SLC9A5,SLC4A8,SLC47A2,CLCN5,SLC7A10,SLC26A3.1,SLC9A4,SLC9A6A,SLC9A3.2 |
| calcium:sodium antiporter activity | SLC8A1B,SLC8A1A,SLC8A2A,SLC8A2B,SLC3A2,SLC8A4A,SLC8A4B,SLC24A6,SLC8A1,SLC8A2 |
| symporter activity | SLC24A5,SLC22A5,SLC16A8,SLC20A1B,SLC1A7A,SLC6A1B,SLC6A2,SLC16A7,SLC17A6,SLC16A12B |
Interacting Protein
SLC24A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC24A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC24A4.
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References
- Herzog, CR; Reid, BM; et al. Hypomaturation amelogenesis imperfecta caused by a novel SLC24A4 mutation. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 119:E77-E81(2015).
- Yu, L; Chibnik, LB; et al. Association of Brain DNA Methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 With Pathological Diagnosis of Alzheimer Disease. JAMA NEUROLOGY 72:15-24(2015).
