SLC24A1
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Official Full Name
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 -
Overview
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein;plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion;of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in;congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been;observed for this gene. -
Synonyms
SLC24A1;solute carrier family 24 (sodium/potassium/calcium exchanger), member 1;sodium/potassium/calcium exchanger 1;HsT17412;KIAA0702;NCKX;NCKX1;RODX;Na(+)/K(+)/Ca(2+) exchange protein 1;Retinal rod Na Ca+K exchanger;Retinal rod Na+/Ca+/K+ exchanger;Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1;Solute carrier family 24 member 1;retinal rod Na-Ca+K exchanger;Na(+)/K(+)/Ca(2+)-exchange protein 1;CSNB1D
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC24A1-1164C | Recombinant Chicken SLC24A1 | Mammalian Cell | Chicken | His |
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| SLC24A1-5465R | Recombinant Rat SLC24A1 Protein | Mammalian Cell | Rat | His |
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| RFL30429BF | Recombinant Full Length Bison Bison Sodium/Potassium/Calcium Exchanger 1(Slc24A1) Protein, His-Tagged | E.coli expression system | Bison bison (American bison) (Bos bison) | His | Full L. Full Length (1-300) |
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| SLC24A1-301340H | Recombinant Human SLC24A1 protein, GST-tagged | E.coli | Human | GST | Glu731-Leu897 |
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| SLC24A1-5124R | Recombinant Rat SLC24A1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC24A1-5124R-B | Recombinant Rat SLC24A1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SLC24A1 involved in several pathways and played different roles in them. We selected most pathways SLC24A1 participated on our site, such as Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC24A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phototransduction | CALM3,CALM3A,RHO,RLN1,GUCA1B,CALM2B,CALML3,GRK1,GNGT1,CALM4 |
Protein Function
SLC24A1 has several biochemical functions, for example, calcium channel activity,calcium ion binding,calcium, potassium:sodium antiporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC24A1 itself. We selected most functions SLC24A1 had, and list some proteins which have the same functions with SLC24A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PVALB7,MMP30,MYL4,PCDH11Y,PCDH1G9,CALM,PON1,FSTL4,EFCAB4B,TESCB |
| sodium ion binding | CAPN3,SCN9A,SLC24A4,SLC24A2,PDXK,SLC24A4A,ATP1A1,SLC24A5,SLC34A2 |
| calcium channel activity | SLC24A2,CACNG8A,CHRNA10,TRPM8,TRPC2B,TRPV5,TRPC7A,CACNG1A,TRPC4B,CACNG7A |
| potassium ion binding | SLC24A4,PKM,HDAC4,SLC24A2,PDXK,ATP1A1,SLC24A4A,PKM2,KCNA4,PKMA |
| symporter activity | SLC6A6A,SLC6A19A,SLC5A8L,SLC17A6,SLC6A1,SLC16A5,SLC6A1B,SLC13A1,SLC6A6B,SLC34A2 |
| calcium, potassium:sodium antiporter activity | SLC24A5,SLC24A4,SLC24A2,SLC24A4A |
Interacting Protein
SLC24A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC24A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC24A1.
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References
- Christopher, M; Scheetz, TE; et al. Selection of Phototransduction Genes in Homo sapiens. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:5489-5496(2013).
- Invergo, BM; Montanucci, L; et al. A system-level, molecular evolutionary analysis of mammalian phototransduction. BMC EVOLUTIONARY BIOLOGY 13:-(2013).
