SLC22A8
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Official Full Name
solute carrier family 22 (organic anion transporter), member 8 -
Overview
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. -
Synonyms
SLC22A8;solute carrier family 22 (organic anion transporter), member 8;solute carrier family 22 member 8;rOat3;organic anion transporter 3;solute carrier family 22 ,member 8;OCT3;Oat3;Roct;MGC93369
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
SLC22A8 involved in several pathways and played different roles in them. We selected most pathways SLC22A8 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC22A8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | Slc4a2,SLC22A7,CYP7A1,ATP1B4,ADCY9,LDLR,SLCO1A2,EPHX1,HMGCR,SLC5A1 |
Protein Function
SLC22A8 has several biochemical functions, for example, inorganic anion exchanger activity,sodium-independent organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC22A8 itself. We selected most functions SLC22A8 had, and list some proteins which have the same functions with SLC22A8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inorganic anion exchanger activity | Slc4a2,SLC4A8,SLC22A9,SLC22A20,SLC4A4A,SLC4A2B,SLC4A1A,SLC4A1,SLC4A1B,SLC22A6 |
| sodium-independent organic anion transmembrane transporter activity | SLCO1C1,SLCO1F1,SLC22A24,SLCO4C1,SLCO1A4,SLCO1A6,SLC22A12,SLC22A7,SLC22A9,SLCO1A2 |
Interacting Protein
SLC22A8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC22A8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC22A8.
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References
- Breljak, D; Brzica, H; et al. Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 304:F1114-F1126(2013).
