SLC22A2
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Official Full Name
solute carrier family 22 (organic cation transporter), member 2 -
Overview
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. -
Synonyms
SLC22A2;solute carrier family 22 (organic cation transporter), member 2;solute carrier family 22 member 2;OCT2;organic cation transporter 2;MGC32628
Recombinant Proteins
- Zebrafish
- Mouse
- Rat
- Human
- Mammalian Cell
- HEK293
- Insect Cell
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Flag&Strep
- His&Flag&MBP
- His&Fc&Avi
- GST
Involved Pathway
SLC22A2 involved in several pathways and played different roles in them. We selected most pathways SLC22A2 participated on our site, such as Choline metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC22A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Choline metabolism in cancer | PLA2G4D,PIK3CA,PIK3CG,GPCPD1,SLC44A2,WASF3,PDGFRB,SLC22A1,PDGFB,RAC3 |
Protein Function
SLC22A2 has several biochemical functions, for example, dopamine transmembrane transporter activity,organic cation transmembrane transporter activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC22A2 itself. We selected most functions SLC22A2 had, and list some proteins which have the same functions with SLC22A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| toxin transporter activity | LRP6,ABCG1,SLC22A3,SLC17A3,SLC7A8 |
| dopamine transmembrane transporter activity | SLC22A1,SLC22A3,SLC6A3 |
| quaternary ammonium group transmembrane transporter activity | SLC22A3,SLC22A5,SLC22A1 |
| organic cation transmembrane transporter activity | SLC7A8,SLC22A14,SLC22A3,SLC22A1 |
| protein binding | TAF1D,TET2,GP1BA,ZNF397,ATXN7,TACR2,SHISA5,DACT2,ZWINT,H2-KE2 |
Interacting Protein
SLC22A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC22A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC22A2.
HYAL3;ETV5;SUMO2;GTF2B;EXT2;CST9L;AGO3;LSM4
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