SLC1A1
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Official Full Name
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -
Overview
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. -
Synonyms
SLC1A1;solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1;excitatory amino acid transporter 3;EAAC1;EAAT3;excitatory amino acid carrier 1;solute carrier family 1 member 1;neuronal and epithelial
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- GST
- His
- T7
- Flag
- Strep
- MBP
- Avi
- Fc
Involved Pathway
SLC1A1 involved in several pathways and played different roles in them. We selected most pathways SLC1A1 participated on our site, such as Glutamatergic synapse,Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | GNAI1,GNB1,HOMER2,PLCB1,PLCB2,SHANK1,PPP3CB,MAPK3,HOMER3,GRIK5 |
| Protein digestion and absorption | FXYD2,KCNK5,PGA4,SLC3A1,COL6A6,KCNJ13,COL6A4,ATP1B2,SLC7A7,KCNN4 |
Protein Function
SLC1A1 has several biochemical functions, for example, L-glutamate transmembrane transporter activity,cysteine transmembrane transporter activity,glutamate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC1A1 itself. We selected most functions SLC1A1 had, and list some proteins which have the same functions with SLC1A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NFKBIL2,GPI1,APOH,FAM49B,UBE2V2,DDOST,DAK,C19orf40,RC3H2,THEMIS2 |
| sodium:dicarboxylate symporter activity | SLC1A7A,SLC1A7,SLC1A3A,SLC13A3,SLC1A9,SLC1A2A,SLC1A6,SLC1A7B,SLC1A5,SLC13A5A |
| glutamate:sodium symporter activity | SLC1A2 |
| L-glutamate transmembrane transporter activity | SLC25A22,SLC1A6,SLC17A8,SLC17A6A,SLC1A2,SLC17A6B,SLC1A3,SLC17A6,SLC25A12,SLC1A7 |
| glutamate binding | SLC1A3,GCLC,GRIK1,GLUL,GRIN2A,GRIN1,GAD2,CPS1,GRM7 |
Interacting Protein
SLC1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC1A1.
LDLRAD1;RNF5;EWSR1
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References
- Li, YC; Zhou, Y; et al. The Rates of Postmortem Proteolysis of Glutamate Transporters Differ Dramatically between Cells and between Transporter Subtypes. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:811-821(2012).
- Holmseth, S; Zhou, Y; et al. Specificity Controls for Immunocytochemistry: The Antigen Preadsorption Test Can Lead to Inaccurate Assessment of Antibody Specificity. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:174-187(2012).
