SIN3B
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Official Full Name
SIN3 transcription regulator homolog B -
Overview
Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene. -
Synonyms
SIN3B;SIN3 transcription regulator homolog B (yeast);SIN3 homolog B, transcription regulator (yeast);paired amphipathic helix protein Sin3b;KIAA0700;transcriptional corepressor Sin3b;SIN3 homolog B, transcription regulator;SIN3 homolog B, transcrip
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SIN3B-4043Z | Recombinant Zebrafish SIN3B | Mammalian Cell | Zebrafish | His |
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| SIN3B-1606HCL | Recombinant Human SIN3B cell lysate | Human | Non |
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Involved Pathway
SIN3B involved in several pathways and played different roles in them. We selected most pathways SIN3B participated on our site, such as Epigenetic regulation of gene expression,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIN3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Negative epigenetic regulation of rRNA expression | RRP8,CD3EAP,DNMT3B,TAF1B,BAZ2A,SAP18,TAF1A,SUDS3,SAP130,SAP30L |
| Gene Expression | EIF5,SFRS3A,ZNF562,MED13A,TSEN34,MED13B,BRF2,POLR3GLA,SMG8,ZNF664 |
| Metabolism | GPHN,DPYD,SCP2B,BHMT2,CYP2N13,MED23,HPSE,SCO1,SULT1C2,ARSF |
| Epigenetic regulation of gene expression | UHRF1,DNMT1,TET2,PHF1,AEBP2,SMARCA5,DNMT3B,SAP18,TET1,PHF19 |
| Metabolism of lipids and lipoproteins | PLIN2,MED16,INSIG1,SACM1LB,APOBB.1,NFYBB,SLCO1B1,LBR,PPM1LA,CETP |
| Hedgehog signaling events mediated by Gli proteins | SAP30,MTSS1,CSNK1G2,KIF3A,LGALS3,IFT88,CSNK1G3,SAP18,SPOP |
| Fatty acid, triacylglycerol, and ketone body metabolism | AGPAT2,MED8,SLC25A20,MED15,MED7,HELZ2,THEM5,AGT,CYP4A11,MED29 |
| NoRC negatively regulates rRNA expression | DNMT3B,TAF1A,SAP30L,BAZ2A,DNMT1,TAF1B,CD3EAP,SAP130,TAF1D,EFCAB11 |
Protein Function
SIN3B has several biochemical functions, for example, RNA polymerase II transcription corepressor activity,chromatin binding,contributes_to histone deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIN3B itself. We selected most functions SIN3B had, and list some proteins which have the same functions with SIN3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | AIRE,PPARG,GLI2,MEN1,SOX9,ELK4,SSRP1,ESR1,NCOA5,SSRP1A |
| RNA polymerase II transcription corepressor activity | OLIG3,SIN3AA,URI1,HDGF,SIN3A,CTBP1,TXLNB,HEYL,RERE,TCERG1 |
| protein binding | TXNRD1,COX5B,DCD,NPDC1,NPBWR2,CLEC7A,PML,SLC9A7,NUP133,KLK6 |
| contributes_to histone deacetylase activity | BRMS1L,BRMS1,SIN3A,SIN3AA,SUDS3,SALL1,BRMS1LA |
Interacting Protein
SIN3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIN3B here. Most of them are supplied by our site. Hope this information will be useful for your research of SIN3B.
HDAC1;MYC;HDAC2;HCFC1;MXD1;PPP1CC;collagen sequence;mdm2_human_probe;pyr1_human_gene;hes1_human_gene;NCL
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References
- Nishibuchi, G; Shibata, Y; et al. Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex. JOURNAL OF BIOLOGICAL CHEMISTRY 289:28956-28970(2014).
- Li, YL; Choi, PS; et al. MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation, and a Neoplastic State. CANCER CELL 26:262-272(2014).
