SIN3A
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Official Full Name
SIN3 transcription regulator homolog A (yeast) -
Overview
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. -
Synonyms
SIN3A;SIN3 transcription regulator homolog A (yeast);SIN3 homolog A, transcription regulator (yeast);paired amphipathic helix protein Sin3a;DKFZP434K2235;KIAA0700;transcriptional regulator, SIN3A;transcriptional corepressor Sin3a;transcriptional co-repressor Sin3A;SIN3 homolog A, transcription regulator;histone deacetylase complex subunit Sin3a;FLJ90319
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SIN3A-2676H | Recombinant Human SIN3A, GST-tagged | E.coli | Human | GST | 1-156aa | |
| SIN3A-15141M | Recombinant Mouse SIN3A Protein | Mammalian Cell | Mouse | His |
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| SIN3A-4205R | Recombinant Rhesus monkey SIN3A Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SIN3A-5539C | Recombinant Chicken SIN3A | Mammalian Cell | Chicken | His |
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| SIN3A-4021R | Recombinant Rhesus Macaque SIN3A Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SIN3A-4021R-B | Recombinant Rhesus Macaque SIN3A Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SIN3A-8177M | Recombinant Mouse SIN3A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SIN3A-8177M-B | Recombinant Mouse SIN3A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SIN3A involved in several pathways and played different roles in them. We selected most pathways SIN3A participated on our site, such as Thyroid hormone signaling pathway,Huntingtons disease,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIN3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | PDGFA,BIRC3,MMP9,FLI1,MAX,MLL1,HPGD,MEF2C,PAX5,IL1R2 |
| Huntingtons disease | MT-ATP6,GPX1,SOD2,DNAH11,DNAH14,CREB3L2,COX5B,COX5A,BBC3,NDUFB10 |
| Thyroid hormone signaling pathway | PFKP,MED24,PIK3R1,BMP4,RXRG,RXRA,PLN,KAT2A,SLC16A2,DIO2 |
Protein Function
SIN3A has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,RNA polymerase II repressing transcription factor binding,RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIN3A itself. We selected most functions SIN3A had, and list some proteins which have the same functions with SIN3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | OST4,TRP63,POU5F3,PARP1,TADA2B,YBX2,SMC1A,PHF21B,APITD1,PHF8 |
| protein deacetylase activity | HDAC2,HDAC4,HDAC1,SIRT2,HDAC3,SIRT1,HDAC9,HDAC5,HDAC10 |
| protein binding | FIP1L1,TGFB1,ROCK2,DOCK4,IL17F,ZFP143,FBXO4,HARS2,MMP2,XRCC1 |
| RNA polymerase II activating transcription factor binding | MAD2L2,ATF2,T,HIPK2,HEY2,NEUROD1,RB1,SMAD3,IFI27,LDB1 |
| contributes_to histone deacetylase activity | SALL1,SIN3B,BRMS1L,BRMS1LA,SUDS3,BRMS1,SIN3AA |
| RNA polymerase II repressing transcription factor binding | MIXL1,MTA1,RBPJ,MKKS,GATA6,BBS1,PPARA,STAT3,BBS4,TBX5A |
| transcription factor activity, sequence-specific DNA binding | HOXB2A,NFIX,ATOH1,FOXH1,KLF6,FOXQ2,ZNF649,RXRBB,HCFC1,ZNF35 |
| RNA polymerase II transcription corepressor activity | TFAP2B,TXLNB,CTBP1,N4BP2L2,RERE,HEYL,URI1,SIN3AA,RBBP8,TLE1 |
| transcription regulatory region sequence-specific DNA binding | NFE2L2,MKL1,PITX2,NKX3-1,NONO,SOX4,NFKB1,NR5A5,SUV39H1,PSPC1 |
Interacting Protein
SIN3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIN3A here. Most of them are supplied by our site. Hope this information will be useful for your research of SIN3A.
HDAC1;HDAC2;SKI;HCFC1
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References
- Zhao, X; Jankovic, V; et al. Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. GENES & DEVELOPMENT 22:640-653(2008).
- Sugimoto, T; Tomita, A; et al. Escape mechanisms from antibody therapy to lymphoma cells: Downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 390:48-53(2009).
