SIM1
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Official Full Name
single-minded homolog 1 -
Overview
Single-minded homolog 1 also known as class E basic helix-loop-helix protein 14 (bHLHe14) is a protein that in humans is encoded by the SIM1 gene. -
Synonyms
SIM1;single-minded homolog 1 (Drosophila);single minded (Drosophila) homolog 1;single-minded homolog 1;bHLHe14;class E basic helix-loop-helix protein 14
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SIM1-15139M | Recombinant Mouse SIM1 Protein | Mammalian Cell | Mouse | His |
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| SIM1-8175M | Recombinant Mouse SIM1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SIM1-8175M-B | Recombinant Mouse SIM1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SIM1 involved in several pathways and played different roles in them. We selected most pathways SIM1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SIM1 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIM1 itself. We selected most functions SIM1 had, and list some proteins which have the same functions with SIM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | GATA3,TFE3B,TFAP2C,MEF2CA,HELT,MXI1,ARNTL1B,HNF1BA,AHR1A,OLIG3 |
| protein heterodimerization activity | TCF3B,JDP2,SUPT4H1,MYF5,ADRA2A,BMP2B,H3F3C,KCNB1,CD3G,BCL2A1A |
| DNA binding | HOXB8A,NR1D4B,HIST1H2AN,LHX1A,IRF6,DMBX1B,FOSL1A,LBX1B,HOXA5A,HIST2H2L |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXN2B,FOXH1,NHLH2,SOX5,PLAGL2,SOX14,ETV5A,FOXO6,RUNX2B,ETV4 |
| transcription factor activity, sequence-specific DNA binding | SMAD3A,CNOT8,HOXA6,ATF6B,CREM,SIX2,NANOG,PPARG,ESR2B,HOXB4A |
| protein binding | RAI2,VPS11,CPNE6,NFE2L2,RPH3A,HOXA3,COMMD2,HDHD2,NOP58,SNX18 |
Interacting Protein
SIM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIM1.
Arnt;Hsp90aa1;Ilk
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References
- Coumailleau, P; Duprez, D; et al. Sim1 and Sim2 expression during chick and mouse limb development. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 53:149-157(2009).
- Zhao, XF; Xu, NY; et al. Single-minded 1 gene mapping and its variants association with growth, carcass composition and meat quality traits in the pig. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 21:941-946(2008).
