SIGMAR1
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Official Full Name
sigma non-opioid intracellular receptor 1 -
Overview
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. -
Synonyms
SIGMAR1;sigma non-opioid intracellular receptor 1;opioid receptor, sigma 1 , OPRS1;SR BP1;SR-BP;SIG-1R;sigma1R;hSigmaR1;SR31747 binding protein 1;sigma 1-type opioid receptor;aging-associated gene 8 protein;SRBP;ALS16;OPRS1;SR-BP1;MGC3851
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Mammalian Cell
- HEK293
- Wheat Germ
- Mamanlian cells
- HEK293T
- In Vitro Cell Free System
- His
- Myc&DDK
- GST
- Non
- Flag
- His&Fc&Avi
Involved Pathway
SIGMAR1 involved in several pathways and played different roles in them. We selected most pathways SIGMAR1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGMAR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SIGMAR1 has several biochemical functions, for example, drug binding,opioid receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGMAR1 itself. We selected most functions SIGMAR1 had, and list some proteins which have the same functions with SIGMAR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| drug binding | UGT1A7,GLRB,PYGL,DCK,CHRNA7,PDE2A,GABRA1,PYGB,SETD6,HMGCS1 |
| opioid receptor activity | NPBWR2,NPBWR1,OPRD1,OPRK1,OPRD1B,OGFR,OPRD1A |
Interacting Protein
SIGMAR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGMAR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGMAR1.
CLN3;PDZD11;pi3p
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References
- Moon, JY; Roh, DH; et al. sigma 1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain. BRITISH JOURNAL OF PHARMACOLOGY 171:5881-5897(2014).
- Lovkvist, H; Jonsson, AC; et al. Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke. BMC NEUROLOGY 14:-(2014).
