SIGLEC9
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Official Full Name
sialic acid binding Ig-like lectin 9 -
Overview
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. -
Synonyms
SIGLEC9;sialic acid binding Ig-like lectin 9;sialic acid-binding Ig-like lectin 9;CD329;protein FOAP-9;CDw329;FOAP-9;siglec-9;OBBP-LIKE
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- E.coli
- Human Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- Fc
- His
- Non
- hIgG4
- His&Avi
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
SIGLEC9 involved in several pathways and played different roles in them. We selected most pathways SIGLEC9 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | SIGLEC12,AMICA1,CD300LH,ICAM4,CLEC2D,CD200,Mill2,LILRB1,CD96,SLAMF6 |
| Adaptive Immune System | LILRB5,TREML1,KIF5A,CD200R3,IGLC2,AP1S3A,MAPKAP1,SEC23A,KIF18A,WSB1 |
| Immune System | IFIT2,BTR09,KIR3DS1,UBE2F,BTR22,ASB18,SAMHD1,TNFSF13B,LGALS9,TXNIPB |
Protein Function
SIGLEC9 has several biochemical functions, for example, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC9 itself. We selected most functions SIGLEC9 had, and list some proteins which have the same functions with SIGLEC9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | ILLR3,FREM1,CD33,CLEC2H,EVA1C,CLEC2G,MAN2B2,SORD,KLRC4-KLRK1,APCS |
Interacting Protein
SIGLEC9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC9 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC9.
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References
- Kardava, L; Moir, S; et al. Attenuation of HIV-associated human B cell exhaustion by siRNA down regulation of inhibitory receptors. JOURNAL OF CLINICAL INVESTIGATION 121:2614-2624(2011).
- Biesen, R; Demir, C; et al. Sialic acid-binding Ig-like lectin I expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus. ARTHRITIS AND RHEUMATISM 58:1136-1145(2008).
