SIGLEC10
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Official Full Name
sialic acid binding Ig-like lectin 10 -
Overview
Siglec-10 is a lectin that specifically binds alpha-2,3- or alpha-2,6-linked sialic acid. It is a member of the Ig-superfamily and is expressed in monocytes, eosinophils, B cells, and a subset of NK cells. Siglec-10 is a single pass transmembrane protein. -
Synonyms
SIGLEC10;sialic acid binding Ig-like lectin 10;sialic acid-binding Ig-like lectin 10;MGC126774;PRO940;sialic acid binding Ig like lectin 10 Ig like lectin 7;SIGLEC 10;siglec like gene 2;SLG2;siglec-like gene 2;siglec-like protein 2;sialic acid
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- HEK293
- C-His
- E.coli
- His
- His&S
- Non
- mFc
- Fc
- Avi&His
- Avi&Fc
- mIgG2a
Involved Pathway
SIGLEC10 involved in several pathways and played different roles in them. We selected most pathways SIGLEC10 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | SIGLEC12,CDKN1B,AGO2,PDPK1A,RNF41,TREML4,KIR2DS2,SEC24A,LAIR2,UBE2V1 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Siglece,LILRA3,SIGLEC12,SIGLEC9,CLEC2B,CLEC2G,SIGLEC6,TREML2,CD160,SIGLEC5 |
| Immune System | DHX9,CFHL3,RNF19B,ADAR,BFB,BTLA,CLEC4A,CTSK,ART1,PANX1B |
Protein Function
SIGLEC10 has several biochemical functions, for example, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC10 itself. We selected most functions SIGLEC10 had, and list some proteins which have the same functions with SIGLEC10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | LGALSLA,SIGLEC8,GALNTL1,LGALS4,GALNT3,GALNT12,SIGLEC12,GALNTL6,CLEC1B,GALNT6 |
Interacting Protein
SIGLEC10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC10 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC10.
PTPN6
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesIg-type Lectins
Dendritic Cell Activation
Dendritic Cell ITIM/ITAM Immunoreceptors
Related Services
Related Products
References
- Rose, T; Grutzkau, A; et al. IFN and its response proteins, IP-10 and SIGLEC-1, are biomarkers of disease activity in systemic lupus erythematosus. ANNALS OF THE RHEUMATIC DISEASES 72:1639-1645(2013).
- Munday, J; Kerr, S; et al. Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. BIOCHEMICAL JOURNAL 355:489-497(2001).
