SHOX2
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Official Full Name
short stature homeobox 2 -
Overview
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. -
Synonyms
SHOX2;short stature homeobox 2;short stature homeobox protein 2;OG12;OG12X;SHOT;Homeobox protein Og12X;OG 12;OG 12X;OGI 2X;OGI2X;Paired related homeobox protein SHOT;Paired-related homeobox protein SHOT;Short stature homeobox homolog;SHOX 2;SHOX homologous gene on chromosome 3;SHOX2_HUMAN;OTTHUMP00000213397;OTTHUMP00000213398;OTTHUMP00000213399;OTTHUMP00000245277
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SHOX2-2665H | Recombinant Human SHOX2, His-tagged | E.coli | Human | His | 1-355aa | |
| SHOX2-11413Z | Recombinant Zebrafish SHOX2 | Mammalian Cells | Zebrafish | His |
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| SHOX2-15111M | Recombinant Mouse SHOX2 Protein | Mammalian Cells | Mouse | His |
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| SHOX2-31358TH | Recombinant Human SHOX2 | Wheat Germ | Human | Non | 88 amino acids |
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| SHOX2-5395R | Recombinant Rat SHOX2 Protein | Mammalian Cells | Rat | His |
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| SHOX2-1604HCL | Recombinant Human SHOX2 cell lysate | Human | Non |
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| SHOX2-5054R | Recombinant Rat SHOX2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SHOX2-5054R-B | Recombinant Rat SHOX2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Shox2-5870M | Recombinant Mouse Shox2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| SHOX2-8160M | Recombinant Mouse SHOX2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SHOX2-8160M-B | Recombinant Mouse SHOX2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SHOX2 involved in several pathways and played different roles in them. We selected most pathways SHOX2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SHOX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SHOX2 has several biochemical functions, for example, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHOX2 itself. We selected most functions SHOX2 had, and list some proteins which have the same functions with SHOX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | KDM6B,RHOXF1,IRX7,ZNF193,Ar,VENTX,NR2F5,TP53,CXXC5,NKX2-5 |
Interacting Protein
SHOX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHOX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHOX2.
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