SHB
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Official Full Name
Src homology 2 domain containing adaptor protein B -
Overview
SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene. -
Synonyms
SHB;Src homology 2 domain containing adaptor protein B;SHB (Src homology 2 domain containing) adaptor protein B , SHB adaptor protein (a Src homology 2 protein);SH2 domain-containing adapter protein B;SHB adaptor protein (a Src homology 2 protein);S
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- His
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SHB-15088M | Recombinant Mouse SHB Protein | Mammalian Cell | Mouse | His |
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| SHB-290H | Recombinant Human SHB Protein, His-tagged | E.coli | Human | His |
|
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| SHB-1948H | Recombinant Human SHB protein, His & T7-tagged | E.coli | Human | His&T7 | Ala252~Arg507 |
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| Shb-1949M | Recombinant Mouse Shb protein, His & T7-tagged | E.coli | Mouse | His&T7 | Ser248~Leu484 |
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| SHB-6281H | Recombinant Human SHB Protein (Ala252-Arg507), N-His tagged | E.coli | Human | His | Ala252-Arg507 |
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| SHB-8139M | Recombinant Mouse SHB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SHB-8139M-B | Recombinant Mouse SHB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SHB involved in several pathways and played different roles in them. We selected most pathways SHB participated on our site, such as Axon guidance,Developmental Biology,EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EPHA-mediated growth cone collapse | EPHA2,EPHA2A,EFNA4,EFNA5,EPHA10,EFNA2A,EFNA1A,KDR,EFNA3,MYL9 |
| Axon guidance | JAK1,NFATC4,KALRNB,NEFLB,RASA1,DOCK1,EFNB3,DPYSL2,AP2A2,MYL12B |
| Signal Transduction | SPOP,RBP4,OXGR1,NPS,RDH14B,MYO7AA,HEYL,INSL3,RHOT1B,PPEF1 |
| EPH-Ephrin signaling | KALRNB,EFNB3,ARPC4,ARPC1B,ARPC5,ARHGEF28,EPHB3A,SDCBP,EFNA1B,ARPC2 |
| T cell receptor signaling pathway | SOS1,Il2,PRKCQ,IKBKG,IL5,CBLB,MAPK9,CD247,PIK3CA,CD4 |
| IL-2 Signaling Pathway | ITM2BA,CISH,CD53,NMI |
| Signaling by VEGF | NRP2A,AXL,DSCAMA,NRP2,JUPA,NRP2B |
| Developmental Biology | CEBPB,SEMA4D,CSNK2B,PEA15,FRS2B,DNM1,LGI2B,DPYSL2,GDF1,EPHB3A |
Protein Function
SHB has several biochemical functions, for example, SH3/SH2 adaptor activity,glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHB itself. We selected most functions SHB had, and list some proteins which have the same functions with SHB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycoprotein binding | CALR,THBS1,EDEM2,CDH1,RAB14,BMPR1A,VWF,ITGAM,SERPINA1E,RGMA |
| SH3/SH2 adaptor activity | CNTNAP1,SH3BGR,RUSC1,BLNK,GAB1,KHDRBS1,SOCS2,GRAP,NCK2,SH2D3C |
Interacting Protein
SHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHB here. Most of them are supplied by our site. Hope this information will be useful for your research of SHB.
Pdgfra;FGFR1
SHB Related Signal Pathway
Resources
Related Services
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References
- Sato, S; Kamada, H; et al. Identification of the Cancer Cell Proliferation and Survival Functions of proHB-EGF by Using an Anti-HB-EGF Antibody. PLOS ONE 8:-(2013).
- Tsuji, I; Sato, S; et al. Characterization of a variety of neutralizing anti-heparin-binding epidermal growth factor-like growth factor monoclonal antibodies by different immunization methods. MABS 4:732-739(2012).
