Shank2
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Official Full Name
SH3 and multiple ankyrin repeat domains 2 -
Synonyms
SHANK2;SH3 and multiple ankyrin repeat domains 2;ENSRNOG00000029931;CortBP1;ProSAP1;Spank-3;1q41;SH3 and multiple ankyrin repeat domains protein 2;SH3 and multiple ankyrin repeat domains protein 2;SH3/ankyrin domain gene 2;cortactin-binding protein 1;GKAP/SAPAP-interacting protein;proline rich synapse associated protein 1;proline-rich synapse-associated protein 1
Recombinant Proteins
- Mouse
- Rat
- Zebrafish
- Human
- HEK293
- Mammalian Cell
- E. coli
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SHANK2-25H |
Recombinant Human SHANK2 protein, His-tagged
|
HEK293 | Mouse | His | Leu34-Val179 |
|
| SHANK2-15085M | Recombinant Mouse SHANK2 Protein | Mammalian Cell | Mouse | His |
|
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| SHANK2-5386R | Recombinant Rat SHANK2 Protein | Mammalian Cell | Rat | His |
|
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| SHANK2-6859Z | Recombinant Zebrafish SHANK2 | Mammalian Cell | Zebrafish | His |
|
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| SHANK2-24H | Recombinant Human SHANK2 protein, His-tagged | E. coli | Human | His | 125-450 aa |
|
| SHANK2-5045R | Recombinant Rat SHANK2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
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| SHANK2-5045R-B | Recombinant Rat SHANK2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SHANK2-8136M | Recombinant Mouse SHANK2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SHANK2-8136M-B | Recombinant Mouse SHANK2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
Shank2 involved in several pathways and played different roles in them. We selected most pathways Shank2 participated on our site, such as Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Shank2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | GRIN2A,SHANK1,GNG13,SLC17A6,SLC38A3,PPP3CA,GNAI2,SLC17A8,GNB2,GRIN3B |
Protein Function
Shank2 has several biochemical functions, for example, SH3 domain binding,ionotropic glutamate receptor binding,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Shank2 itself. We selected most functions Shank2 had, and list some proteins which have the same functions with Shank2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | DOCK1,GRB2,AFAP1L2,ITGB1BP2,CD2AP,PAK3,KHDRBS3,ABL1,CCDC6,SIRPA |
| protein C-terminus binding | ID1,RAD51,MAP3K7,MIF4GD,SAE1,VAMP2,NCF2,VPS4B,MAP2K1,PXK |
| ionotropic glutamate receptor binding | ADRB2,DLG4B,CACNG2,GNAS,NETO1,FLOT2,DLG1,SHANK1,IL1R1,DLG3 |
Interacting Protein
Shank2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Shank2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Shank2.
Grin1;Pde4d;Grin2b;Ywhab
Resources
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References
- Heo, JW; Kim, JH; et al. Inhibitory Activity of Bevacizumab to Differentiation of Retinoblastoma Cells. PLOS ONE 7:-(2012).
- Raab, M; Boeckers, TM; et al. PROLINE-RICH SYNAPSE-ASSOCIATED PROTEIN-1 AND 2 (ProSAP1/Shank2 AND ProSAP2/Shank3)-SCAFFOLDING PROTEINS ARE ALSO PRESENT IN POSTSYNAPTIC SPECIALIZATIONS OF THE PERIPHERAL NERVOUS SYSTEM. NEUROSCIENCE 171:421-433(2010).
