SH3RF1
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Official Full Name
SH3 domain containing ring finger 1 -
Overview
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. -
Synonyms
SH3RF1;SH3 domain containing ring finger 1;SH3 multiple domains 2 , SH3MD2;E3 ubiquitin-protein ligase SH3RF1;KIAA1494;plenty of SH3 domains;POSH;RNF142;FLJ21602;Plenty of SH3s;Ring finger protein 142;RNF 142;SH3 domain containing RING finger protein 1;SH3 multiple domains 2;OTTHUMP00000219547;SH3 multiple domains protein 2;SH3 domain-containing RING finger protein 1;putative E3 ubiquitin-protein ligase SH3RF;SH3MD2
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SH3RF1-2652H | Recombinant Human SH3RF1, GST-tagged | E.coli | Human | GST | 696-1056aa | |
| SH3RF1-3932Z | Recombinant Zebrafish SH3RF1 | Mammalian Cells | Zebrafish | His |
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| SH3RF1-4417Z | Recombinant Zebrafish SH3RF1 | Mammalian Cells | Zebrafish | His |
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| SH3RF1-5382R | Recombinant Rat SH3RF1 Protein | Mammalian Cells | Rat | His |
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| SH3RF1-1864HCL | Recombinant Human SH3RF1 293 Cell Lysate | HEK293 | Human | Non |
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| SH3RF1-3097H | Recombinant Human SH3RF1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| SH3RF1-5041R | Recombinant Rat SH3RF1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| SH3RF1-5041R-B | Recombinant Rat SH3RF1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Sh3rf1-5851M | Recombinant Mouse Sh3rf1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
SH3RF1 involved in several pathways and played different roles in them. We selected most pathways SH3RF1 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH3RF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class I MHC mediated antigen processing & | CMTM2A,HECTD3,VPRBP,ASB18,NPEPPS,UFL1,RNF138,RNF111,RNF6,ERAP1 |
| Adaptive Immune System | RNF123,ARF1,LAIR2,CD200R2,RNF144B,ICAM4,OSCAR,CTSO,AHCYL1,ITK |
| presentation | CYBA,ASB18,SEC61B,ASB6,ASB13,LRRC41,TRIM41,CTSS,ASB11,HECTD3 |
| G13 Signaling Pathway | ARHGEF1A,MYL1,MYBPH,TNK2,GNA13,CFL2,DIAPH1,RTKN,RHPN2,CIT |
| Immune System | HUWE1,CRTAM,SEC24A,NLRP4E,MX2,TREX1,BTR30,CD300LD,CD300LB,MKRN1 |
| Antigen processing: Ubiquitination & | RNF111,ASB4,ARIH2,HUWE1,NPEPPS,RNF19B,MKRN1,UBR2,STUB1,CMTM2A |
| Proteasome degradation | RNF111,RNF19B,TRIM63,ASB17,TRIM69,RNF14,ATG7,LRR1,ARIH2,SPSB2 |
Protein Function
SH3RF1 has several biochemical functions, for example, ligase activity,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH3RF1 itself. We selected most functions SH3RF1 had, and list some proteins which have the same functions with SH3RF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ANTXR1,MAT2B,MTPAP,ZNF193,HNRNPD,ZDHHC13,MYF5,CEP170L,CRB1,XAGE3 |
| zinc ion binding | ZCCHC17,SIAH1,TNFAIP3,LMO1,MME,CDADC1,CUL9,AGBL3,CAR5A,CA12 |
| ligase activity | RNF144AB,NAPRT1,DTX1,RTCB,UBE2L3A,RNF2,MID1,NSMCE2,PJA1,TRIM4 |
Interacting Protein
SH3RF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH3RF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH3RF1.
RAC1;SIAH2;AKT1;AKT2;UBC;PAK2;ADAM15;MAP4K3;SEMA6A;MYC;YWHAB
Resources
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References
- Kim, TW; Kang, YK; et al. SH3RF2 functions as an oncogene by mediating PAK4 protein stability. CARCINOGENESIS 35:624-634(2014).
- Karkkainen, S; van der Linden, M; et al. POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. FEBS LETTERS 584:3867-3872(2010).
